Several reports have demonstrated that tumours are not intrinsically resistant to the immune
response. However, neoplasias commonly fail to initiate and maintain adequate immunity. A …

Dendritic cells (DC) are central to the initiation of immunity. To induce immune reactivity, DC
are recruited at the site of antigen expression, uptake antigens and migrate to secondary …

The complexity of the tumor immunoenvironment is underscored by the emergence and
discovery of different subsets of immune effectors and regulatory cells. Tumor-induced …

The failure of the immune system to provide protection against tumour cells is an important
immunological problem. It is now evident that inadequate function of the host immune …

The fact that the immune response to cancer is compromised has been convincingly
demonstrated in murine tumor models as well as in cancer patients. The unresponsiveness …

Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to
affect disease progression in many human malignancies. Infiltration by mature, active DCs …

Highlights•All major subsets of DCs are critical component of anti-tumor immunity.•DCs in
TME show defects in differentiation, activation and functions.•The presence inf-DCs with anti …

Dendritic cells (DC) are key regulators of both innate and adaptive immunity, and the array
of immunoregulatory functions exhibited by these cells is dictated by their differentiation …

Defective dendritic cell (DC) function has been described previously in cancer patients and
tumor-bearing mice. It can be an important factor in the escape of tumors from immune …

Dendritic cells (DCs) are antigen-presenting cells specialized to initiate and maintain
immunity and tolerance. DCs initiate immune responses in a manner that depends on …