Integrated placental modelling of histology with gene expression to identify functional impact on fetal growth

HEJ Yong, K Maksym, MAB Yusoff, E Salazar-Petres… - medRxiv, 2022 - medrxiv.org
Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Altered
placental formation and functional capacity are major contributors to FGR pathogenesis …

Integrated placental modelling of histology with gene expression to identify functional impact on fetal growth

HEJ Yong, K Maksym, MAB Yusoff, E Salazar-Petres… - Cells, 2023 - mdpi.com
Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Altered
placental formation and functional capacity are major contributors to FGR pathogenesis …

In vivo textural and morphometric analysis of placental development in healthy & growth-restricted pregnancies using magnetic resonance imaging

N Andescavage, S Dahdouh, M Jacobs, S Yewale… - Pediatric …, 2019 - nature.com
Background The objective of this study was to characterize structural changes in the healthy
in vivo placenta by applying morphometric and textural analysis using magnetic resonance …

The placental basis of fetal growth restriction

RL Zur, WT Parks, SR Hobson - Obstetrics and Gynecology …, 2020 - obgyn.theclinics.com
The past decade has seen a substantial advancement in our understanding of placental
diseases that are associated with fetal growth restriction (FGR). 1 This increased …

The placenta in fetal growth restriction: what is going wrong?

C Sun, KM Groom, C Oyston, LW Chamley, AR Clark… - Placenta, 2020 - Elsevier
The placenta is essential for the efficient delivery of nutrients and oxygen from mother to
fetus to maintain normal fetal growth. Dysfunctional placental development underpins many …

Towards deep cellular phenotyping in placental histology

M Ferlaino, CA Glastonbury, C Motta-Mejia… - arXiv preprint arXiv …, 2018 - arxiv.org
The placenta is a complex organ, playing multiple roles during fetal development. Very little
is known about the association between placental morphological abnormalities and fetal …

Placental function and the development of fetal overgrowth and fetal growth restriction

JH Dumolt, TL Powell… - Obstetrics and Gynecology …, 2021 - obgyn.theclinics.com
The developing fetus undergoes a dynamic period of rapid growth that is responsive to
changes in the in utero environment that may contribute to the development of fetal growth …

Mechanistic insights into the development of severe fetal growth restriction

DL Gumina, EJ Su - Clinical Science, 2023 - portlandpress.com
Fetal growth restriction (FGR), which most commonly results from suboptimal placental
function, substantially increases risks for adverse perinatal and long-term outcomes. The …

In vivo placental MRI shape and textural features predict fetal growth restriction and postnatal outcome

S Dahdouh, N Andescavage, S Yewale… - Journal of Magnetic …, 2018 - Wiley Online Library
Purpose To investigate the ability of three‐dimensional (3D) MRI placental shape and
textural features to predict fetal growth restriction (FGR) and birth weight (BW) for both …

Three-Dimensional In Vitro Human Placental Organoids from Mononuclear Villous Trophoblasts or Trophoblast Stem Cells to Understand Trophoblast Dysfunction in …

C Sun, JL James, P Murthi - Trophoblasts: Methods and Protocols, 2023 - Springer
The placenta plays a critical role in the efficient delivery of nutrients and oxygen from mother
to fetus to maintain normal fetal growth. Human placental development and function is a …