Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?

NK Brogden, KA Brogden - International journal of antimicrobial agents, 2011 - Elsevier
The concept of antimicrobial peptides (AMPs) as potent pharmaceuticals is firmly
established in the literature, and most research articles on this topic conclude by stating that …

The therapeutic applications of antimicrobial peptides (AMPs): a patent review

HK Kang, C Kim, CH Seo, Y Park - Journal of microbiology, 2017 - Springer
Antimicrobial peptides (AMPs) are small molecules with a broad spectrum of antibiotic
activities against bacteria, yeasts, fungi, and viruses and cytotoxic activity on cancer cells, in …

[图书][B] Antimicrobial peptides: basics for clinical application

K Matsuzaki - 2019 - Springer
Antimicrobial peptides (AMPs) discovered about 30 years ago are responsible for part of the
innate immunity of animals and plants, and almost 3000 peptides have been reported so far …

Development and challenges of antimicrobial peptides for therapeutic applications

CH Chen, TK Lu - Antibiotics, 2020 - mdpi.com
More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have
been approved by the US Food and Drug Administration (FDA). Now commercialized, these …

Antimicrobial peptides: therapeutic potentials

SJ Kang, SJ Park, T Mishig-Ochir… - Expert review of anti …, 2014 - Taylor & Francis
The increasing appearance of multidrug-resistant pathogens has created an urgent need for
suitable alternatives to current antibiotics. Antimicrobial peptides (AMPs), which act as …

Antimicrobial peptides: an introduction

EF Haney, SC Mansour, REW Hancock - Antimicrobial peptides: methods …, 2017 - Springer
The “golden era” of antibiotic discovery has long passed, but the need for new antibiotics
has never been greater due to the emerging threat of antibiotic resistance. This urgency to …

Antimicrobial peptides as potential therapeutic agents: a review

S Datta, A Roy - International Journal of Peptide Research and …, 2021 - Springer
The growth of pathogens across the globe is developing at a very fast rate, thus turning into
a worldwide health problem. Since, current treatment alternatives have failed to a large …

Antimicrobial peptides: mechanism of action, activity and clinical potential

QY Zhang, ZB Yan, YM Meng, XY Hong, G Shao… - Military Medical …, 2021 - Springer
The management of bacterial infections is becoming a major clinical challenge due to the
rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome …

Antimicrobial peptides (AMPs): A promising class of antimicrobial compounds

M Erdem Büyükkiraz, Z Kesmen - Journal of applied …, 2022 - academic.oup.com
Antimicrobial peptides (AMPs) are compounds, which have inhibitory activity against
microorganisms. In the last decades, AMPs have become powerful alternative agents that …

Antimicrobial peptides (AMPs): peptide structure and mode of action

YK Park, KS Hahm - BMB Reports, 2005 - koreascience.kr
Antimicrobial peptides (AMPs) have been isolated and characterized from tissues and
organisms representing virtually every kingdom and phylum. Their amino acid composition …