Phagocytosis controls CNS homeostasis by facilitating the removal of unwanted cellular
debris. Accordingly, impairments in different receptors or proteins involved in phagocytosis …

The accumulation of amyloid-β-containing neuritic plaques and intracellular tau protein
tangles are key histopathological hallmarks of Alzheimer's disease (AD). This type of …

Beclin 1 is a protein involved in the regulation of autophagy and has been shown to be
reduced in patients with Alzheimer disease. This review summarizes the current research …

The molecular mechanism of autophagy and its relationship to other lysosomal degradation
pathways remain incompletely understood. Here, we identified a previously uncharacterized …

Autophagy is the principal cellular pathway for degradation of long-lived proteins and
organelles and regulates cell fate in response to stress. Recently, autophagy has been …

Deficiency of autophagy protein beclin 1 is implicated in tumorigenesis and
neurodegenerative diseases, but the molecular mechanism remains elusive. Previous …

Autophagy is an intracellular degradation pathway that functions in protein and organelle
turnover in response to starvation and cellular stress. Autophagy is initiated by the formation …

Beclin 1, the mammalian orthologue of yeast Atg6, has a central role in autophagy, a
process of programmed cell survival, which is increased during periods of cell stress and …

Alzheimer's disease is characterized not only by extracellular amyloid plaques and
neurofibrillary tangles, but also by microglia‐mediated neuroinflammation. Recently …

During autophagy, a double membrane envelops cellular material for trafficking to the
lysosome. Human beclin-1 and its yeast homologue, Atg6/Vps30, are scaffold proteins …