The most challenging aspect of treating alcohol and drug addiction is the relapsing course of
these disorders. Although substitution therapies for nicotine and opioid dependence have …

Despite the fact that the use of alcohol, nicotine and other drugs is the major external factor
contributing to mortality in industrialised countries, there are few medications available to …

Long-term alcohol exposure leads to the development of alcohol dependence, which is
possibly induced by changes in specific neurotransmitter functions. Accumulating evidence …

Glutamate plays a pivotal role in drug addiction, and the N-methyl-d-aspartate (NMDA)
glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this …

Glutamate is the brain's principal Glutamate is the brain's principal excitatory
neurotransmitter for which there are three receptors–the ion channels N-methyl-D-aspartate …

Alcohol addiction is a costly and detrimental chronic relapsing disorder, characterized by
compulsive alcohol use despite the negative consequences; it is thought to be associated …

Because of its widespread involvement in the physiology and pathology of the CNS, the
glutamatergic system has gained considerable attention as a potential target for …

Convulsions associated with cocaine abuse can be life threatening and resistant to standard
emergency treatment. Cocaine (75 mg/kg, ip) produced clonic convulsions in∼ 90% of …

Modulators of glutamate receptors especially of the N-methyl-d-aspartate receptors
(NMDARs) have recently been suggested as putative pharmacotherapeutic agents in the …

This paper reviews clinical evidence suggesting that antagonism of the N‐methyl‐d‐
aspartate subtype of glutamate receptors by ethanol may convey an important component of …