Cells come in a huge variety of shapes and sizes, from the almost spherical lymphocyte, to
amoeboid cells such as macrophages, to flattened spindle-shaped fibroblasts or polygonal …

Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …

Janmey, Paul A. The Cytoskeleton and Cell Signaling: Component Localization and
Mechanical Coupling. Physiol. Rev. 78: 763–781, 1998.—The three-dimensional …

Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …

There has been growing interest in the axon as the initial focus of pathological change in a
number of neurodegenerative diseases of the central nervous system. This review …

Synaptic spine morphology is controlled by the activity of Rac1, Cdc42 and RhoA, which
need to be finely balanced, and in particular RhoA/ROCK prevents the formation of new …

Cdk5 kinase, a cyclin-dependent kinase family member, is a key regulator of cytoskeletal
remodeling in the brain. Cdk5 is essential for brain development during embryogenesis …

Abstract Alzheimer's disease (AD), a multifactorial disease, is characterized by the
accumulation of neurofibrillary tangles (NFTs) and amyloid beta (Aβ) plaques. AD is …

During interphase, filamentous actin, microtubules, and intermediate filaments regulate cell
shape, motility, transport, and interactions with the environment. These activities rely on …

Immune cells are especially dependent on the proper functioning of the actin cytoskeleton,
and both innate and adaptive responses rely on it. Leukocytes need to adhere not only to …