Design of novel bioconjugates for targeted drug delivery

ZR Lu, JG Shiah, S Sakuma, P Kopečková… - Journal of controlled …, 2002 - Elsevier
This paper summarizes recent work on the design and development of targeted polymeric
bioconjugates based on N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers …

Synthesis of Bioadhesive Lectin-HPMA Copolymer− Cyclosporin Conjugates

ZR Lu, SQ Gao, P Kopecková… - Bioconjugate …, 2000 - ACS Publications
An amino group containing cyclosporin A (CsA) derivative has been synthesized and
conjugated to N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer via an aromatic azo …

HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity

K Ulbrich, T Etrych, P Chytil, M Jelınková… - Journal of Controlled …, 2003 - Elsevier
Data on the synthesis, physicochemical characterisation and in vitro and in vivo biological
properties of the new, nontargeted or antibody-targeted polymer–doxorubicin conjugates …

Development of HPMA copolymer–anticancer conjugates: clinical experience and lessons learnt

R Duncan - Advanced drug delivery reviews, 2009 - Elsevier
The concept of polymer–drug conjugates was proposed more than 30 years ago, and an N-
(2-hydroxypropyl) methacrylamide (HPMA) copolymer conjugate of doxorubicin covalently …

New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties

T Etrych, M Jelı́nková, B Řı́hová, K Ulbrich - Journal of Controlled Release, 2001 - Elsevier
In this paper we describe the synthesis, physico-chemical characteristics and results of tests
of biological activity of polymer drugs based on conjugates of anti-cancer drug doxorubicin …

HPMA copolymer–drug conjugates with controlled tumor‐specific drug release

P Chytil, E Koziolová, T Etrych… - Macromolecular …, 2018 - Wiley Online Library
Over the past few decades, numerous polymer drug carrier systems are designed and
synthesized, and their properties are evaluated. Many of these systems are based on water …

Synthetic polymers conjugated to monoclonal antibodies: vehicles for tumour-targeted drug delivery

LENW SEYMOUR, PA FLANAGAN… - Selective cancer …, 1991 - liebertpub.com
ABSTRACT (N-(2-Hydroxypropyl) methacrylamide (HPMA)) copolymers have seen
extensive development as sophisticated lysosomotropic drug carriers. They can be used for …

Potential of lectin-N-(2-hydroxypropyl) methacrylamide copolymer-drug conjugates for the treatment of pre-cancerous conditions

S Wroblewski, M Berenson, P Kopečková… - Journal of controlled …, 2001 - Elsevier
N-(2-Hydroxypropyl) methacrylamide (HPMA)-lectin (wheat germ agglutinin (WGA), peanut
agglutinin (PNA)) drug conjugates for treatment of the pre-cancerous conditions ulcerative …

Star structure of antibody-targeted HPMA copolymer-bound doxorubicin: a novel type of polymeric conjugate for targeted drug delivery with potent antitumor effect

M Kovář, J Strohalm, T Etrych, K Ulbrich… - Bioconjugate …, 2002 - ACS Publications
The aim of this study was to compare the properties and antitumor potential of a novel type
of antibody-targeted N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer-bound …

Biorecognizable HPMA copolymer–drug conjugates for colon-specific delivery of 9-aminocamptothecin

S Sakuma, ZR Lu, P Kopečková, J Kopeček - Journal of controlled release, 2001 - Elsevier
N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer conjugates for colon-specific
delivery of 9-aminocamptothecin (9-AC) were designed. They hold 9-AC bound via spacers …