Design of novel bioconjugates for targeted drug delivery
ZR Lu, JG Shiah, S Sakuma, P Kopečková… - Journal of controlled …, 2002 - Elsevier
This paper summarizes recent work on the design and development of targeted polymeric
bioconjugates based on N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers …
bioconjugates based on N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers …
Synthesis of Bioadhesive Lectin-HPMA Copolymer− Cyclosporin Conjugates
ZR Lu, SQ Gao, P Kopecková… - Bioconjugate …, 2000 - ACS Publications
An amino group containing cyclosporin A (CsA) derivative has been synthesized and
conjugated to N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer via an aromatic azo …
conjugated to N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer via an aromatic azo …
HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity
Data on the synthesis, physicochemical characterisation and in vitro and in vivo biological
properties of the new, nontargeted or antibody-targeted polymer–doxorubicin conjugates …
properties of the new, nontargeted or antibody-targeted polymer–doxorubicin conjugates …
Development of HPMA copolymer–anticancer conjugates: clinical experience and lessons learnt
R Duncan - Advanced drug delivery reviews, 2009 - Elsevier
The concept of polymer–drug conjugates was proposed more than 30 years ago, and an N-
(2-hydroxypropyl) methacrylamide (HPMA) copolymer conjugate of doxorubicin covalently …
(2-hydroxypropyl) methacrylamide (HPMA) copolymer conjugate of doxorubicin covalently …
New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties
T Etrych, M Jelı́nková, B Řı́hová, K Ulbrich - Journal of Controlled Release, 2001 - Elsevier
In this paper we describe the synthesis, physico-chemical characteristics and results of tests
of biological activity of polymer drugs based on conjugates of anti-cancer drug doxorubicin …
of biological activity of polymer drugs based on conjugates of anti-cancer drug doxorubicin …
HPMA copolymer–drug conjugates with controlled tumor‐specific drug release
Over the past few decades, numerous polymer drug carrier systems are designed and
synthesized, and their properties are evaluated. Many of these systems are based on water …
synthesized, and their properties are evaluated. Many of these systems are based on water …
Synthetic polymers conjugated to monoclonal antibodies: vehicles for tumour-targeted drug delivery
LENW SEYMOUR, PA FLANAGAN… - Selective cancer …, 1991 - liebertpub.com
ABSTRACT (N-(2-Hydroxypropyl) methacrylamide (HPMA)) copolymers have seen
extensive development as sophisticated lysosomotropic drug carriers. They can be used for …
extensive development as sophisticated lysosomotropic drug carriers. They can be used for …
Potential of lectin-N-(2-hydroxypropyl) methacrylamide copolymer-drug conjugates for the treatment of pre-cancerous conditions
S Wroblewski, M Berenson, P Kopečková… - Journal of controlled …, 2001 - Elsevier
N-(2-Hydroxypropyl) methacrylamide (HPMA)-lectin (wheat germ agglutinin (WGA), peanut
agglutinin (PNA)) drug conjugates for treatment of the pre-cancerous conditions ulcerative …
agglutinin (PNA)) drug conjugates for treatment of the pre-cancerous conditions ulcerative …
Star structure of antibody-targeted HPMA copolymer-bound doxorubicin: a novel type of polymeric conjugate for targeted drug delivery with potent antitumor effect
M Kovář, J Strohalm, T Etrych, K Ulbrich… - Bioconjugate …, 2002 - ACS Publications
The aim of this study was to compare the properties and antitumor potential of a novel type
of antibody-targeted N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer-bound …
of antibody-targeted N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer-bound …
Biorecognizable HPMA copolymer–drug conjugates for colon-specific delivery of 9-aminocamptothecin
N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer conjugates for colon-specific
delivery of 9-aminocamptothecin (9-AC) were designed. They hold 9-AC bound via spacers …
delivery of 9-aminocamptothecin (9-AC) were designed. They hold 9-AC bound via spacers …