Human T-cell leukemia virus type-1 (HTLV-1) is an oncogenic retrovirus estimated to have
infected 5-10 million individuals across the globe (1). HTLV-1 belongs to the Deltaretrovirus …

To establish infection, a retrovirus must insert a DNA copy of its RNA genome into host
chromatin. This reaction is catalysed by the virally encoded enzyme integrase (IN) and is …

Understanding of the structures and functions of the retroviral integrase (IN), a key enzyme
in the viral replication cycle, is essential for developing antiretroviral treatments and …

The human T-cell leukemia virus type-2 (HTLV-2) integrase (IN) catalyzes the insertion of
the viral genome into the host chromosome. HTLV-2 IN was expressed as an N-terminal …

Despite the widespread nature of HTLV-II in New World populations and intravenous drug
users, the enzymatic activities of thepolgenes have not been reported. To ascertain the …

Human immunodeficiency virus type I (HIV-I), is a human retrovirus that is the causative
agent of acquired immune deficiency syndrome (AIDS). Retroviruses replicate through a …

More than 10 million people worldwide are infected with the retrovirus human T-cell
lymphotropic virus type 1 (HTLV-1). Infection phenotypes can range from asymptomatic to …

Retroviral infections cause a variety of cancers in animals and a number of diverse diseases
in humans such as leukemia and acquired immune deficiency syndrome. Productive and …

The C‐terminal part of the pol gene of the human T‐cell leukemia virus type I (HTLV‐I) is
predicted to encode the integrase (IN) of the virus; however, this protein has not yet been …

Human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus most prevalent in
southwestern Japan, sub-Saharan Africa, Australia, South America, and the Caribbean …