C5aR1, the proinflammatory receptor for C5a, is expressed in the central nervous system on
microglia, endothelial cells, and neurons. Previous work demonstrated that the C5aR1 …

Multiple studies have recognized the involvement of the complement cascade during
Alzheimer's disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the …

Background Pharmacologic inhibition of C5aR1, a receptor for the complement activation
proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in Alzheimer's …

Alzheimer's disease (AD) is the leading cause of dementia in older adults, and the need for
effective, sustainable therapeutic targets is imperative. The complement pathway has been …

In this study we explored the potential role of the complement derived anaphylatoxin C5a
and the expression of its receptor in mouse brain. Using in situ hybridization, we found that …

Expression of C1q, an early component of the classical complement pathway, has been
shown to be induced in neurons in hippocampal slices, following accumulation of …

According to the amyloid hypothesis of Alzheimer's disease (AD) the deposition of prefibrillar
and fibrillar Aβ peptide sets off the pathogenic cascades of neuroinflammation and …

Background The complement system is part of the innate immune system that clears
pathogens and cellular debris. In the healthy brain, complement influences …

Alzheimer's disease (AD) is an age-related dementia, characterized by amyloid plaques,
neurofibrillary tangles, neuroinflammation, and neuronal loss in the brain. Components of …

Background Alzheimer's disease (AD) is a neurodegenerative dementia characterized by
the decline of cognition and the presence of neuropathological changes including neuronal …