Reversible histone acetylation is one of the key mechanisms involved in the epigenetic
control of gene expression. A variety of recent studies has revealed a role for acetylation in a …

Histone deacetylase (HDAC) catalyze deacetylation of acetylated lysine residues on
histones and a growing number of nonhistone proteins including many transcription factors …

Epigenetics as well as post-translational modifications of proteins are emerging as novel
attractive targets for anti-cancer therapy. Histone acetyltransferases (HATs) and histone …

Together, histone acetyltransferases and histone deacetylases (HDACs) determine the
acetylation status of histones. This acetylation affects the regulation of gene expression, and …

Histone deacetylase (HDAC) inhibitors are a new class of targeted anticancer agents.
Several HDAC inhibitors are in clinical trials and have shown significant activity against a …

Histone deacetylase (HDAC) inhibitors are emerging as an exciting new class of potential
anticancer agents for the treatment of solid and hematological malignancies. In recent years …

Transformed cells, characterised by inappropriate cell proliferation, do not necessarily lose
the capacity to undergo growth arrest under certain stimuli. DNA, genetic information, is …

The reversible histone acetylation and deacetylation are epigenetic phenomena that play
critical roles in the modulation of chromatin topology and the regulation of gene expression …

Regulation of gene expression is mediated by several mechanisms such as DNA
methylation, ATP-dependent chromatin remodeling, and post-translational modifications of …

Histone deacetylase (HDAC) inhibitors are an exciting new addition to the arsenal of cancer
therapeutics. The inhibition of HDAC enzymes by HDAC inhibitors shifts the balance …