Multiple sclerosis (MS) lesions in the CNS are characterized by disseminated demyelination
with perivascular infiltrates of macrophages, T cells, and B cells. To investigate the origin …

Single-cell RT-PCR was used to sample CD19+ B cell repertoires in cerebrospinal fluid
(CSF) of patients with multiple sclerosis (MS) or viral meningitis. Analysis of amplified Ab H …

In the central nervous system of patients with multiple sclerosis, B cell aggregates populate
the meninges, raising the central question as to whether these structures relate to the B cell …

The accumulation of B lymphocyte clones in the cerebrospinal fluid (CSF) of patients with
multiple sclerosis (MS) and patients with other neurological disorders was investigated …

Clonally expanded populations of B cells carrying somatic mutations of Ig variable (V) region
genes have been detected in the CNS of subjects with multiple sclerosis (MS), suggesting …

The development of somatically mutated memory and plasma B cells is a consequence of T
cell-dependent antigen-challenged humoral immunity. To investigate the role of B cell …

The cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients is characterized by
increased concentrations of immunoglobulin (Ig), which on electrophoretic analysis shows …

Increased amounts of intrathecally synthesized IgG and oligoclonal bands have long been
recognized as a hallmark of multiple sclerosis (MS). B cells and plasma cells are …

Multiple sclerosis (MS) cerebrospinal fluid and brain contain increased IgG and oligoclonal
bands. Whether this oligoclonal and polyclonal IgG is directed against a disease‐relevant …

Myelin basic protein (MBP)‐reactive T cells are thought to play an important role in the
pathogenesis of multiple sclerosis (MS). In some patients with MS, these autoreactive T cells …