Overexpression of SSTR2 inhibited the growth of SSTR2-positive tumors via multiple signaling pathways
T Zhou, X Xiao, B Xu, H Li, Y Zou - Acta oncologica, 2009 - Taylor & Francis
Background. Somatostatin receptors (SSTR1-5) are inhibitory G-protein coupled receptors
that are ubiquitously expressed in both normal and cancer cells. Activation of SSTRs results …
that are ubiquitously expressed in both normal and cancer cells. Activation of SSTRs results …
Somatostatin analogues inhibit cancer cell proliferation in an SSTR2-dependent manner via both cytostatic and cytotoxic pathways
Y Zou, X Xiao, Y Li, T Zhou - Oncology reports, 2009 - spandidos-publications.com
Somatostatin receptors (SSTRs) are inhibitory G-protein coupled receptors that are
ubiquitously expressed in normal and cancer cells. Somatostatins (SST) are the natural …
ubiquitously expressed in normal and cancer cells. Somatostatins (SST) are the natural …
[HTML][HTML] Coexpression of human somatostatin receptor-2 (SSTR2) and SSTR3 modulates antiproliferative signaling and apoptosis
SA War, U Kumar - Journal of molecular signaling, 2012 - Springer
Somatostatin (SST) via five Gi coupled receptors namely SSTR1-5 is known to inhibit cell
proliferation by cytostatic and cytotoxic mechanisms. Heterodimerization plays a crucial role …
proliferation by cytostatic and cytotoxic mechanisms. Heterodimerization plays a crucial role …
Somatostatin receptor gene transfer inhibits established pancreatic cancer xenografts
SA Celinski, WE Fisher, F Amaya, YQ Wu, Q Yao… - Journal of Surgical …, 2003 - Elsevier
Background. Most human pancreatic adenocarcinoma cells do not express somatostatin
receptors, and somatostatin does not inhibit the growth of these cancers. We have …
receptors, and somatostatin does not inhibit the growth of these cancers. We have …
[HTML][HTML] Expression and selective activation of somatostatin receptor subtypes induces cell cycle arrest in cancer cells
YI Zou, H Tan, Y Zhao, Y Zhou… - Oncology …, 2019 - spandidos-publications.com
Somatostatin receptors (SSTRs) are G‑protein‑coupled plasma membrane receptors that
have been determined to be expressed in normal and cancer tissues. Activation of SSTRs …
have been determined to be expressed in normal and cancer tissues. Activation of SSTRs …
Transfection of SSTR-1 and SSTR-2 inhibits Panc-1 cell proliferation and renders Panc-1 cells responsive to somatostatin analogue
M Li, R Zhang, F Li, H Wang, HJ Kim, L Becnel… - Journal of the American …, 2005 - Elsevier
BACKGROUND: Somatostatin inhibits cell proliferation through interaction with its cellular
receptor, somatostatin receptors (SSTRs). We have previously demonstrated that …
receptor, somatostatin receptors (SSTRs). We have previously demonstrated that …
Detection of somatostatin receptor subtype 2 (SSTR2) in established tumors and tumor cell lines: evidence for SSTR2 heterogeneity
JE Taylor, MA Theveniau, R Bashirzadeh, T Reisine… - Peptides, 1994 - Elsevier
The somatostatin receptor subtype 2 (SSTR2) was detected in a wide range of human and
rat tumors using in vitro receptor binding ([125 I] MK-678), receptor gene expression …
rat tumors using in vitro receptor binding ([125 I] MK-678), receptor gene expression …
Mechanisms of inhibition of growth of human pancreatic carcinoma implanted in nude mice by somatostatin receptor subtype 2
M Kumar, ZR Liu, L Thapa, DY Wang, R Tian, RY Qin - Pancreas, 2004 - journals.lww.com
Objectives: Several studies reported that somatostatin receptor subtypes, especially subtype
2 (SSTR2), exerted their cytostatic and/or cytotoxic effects on various types of tumors. The …
2 (SSTR2), exerted their cytostatic and/or cytotoxic effects on various types of tumors. The …
Somatostatin receptor‐1 induces cell cycle arrest and inhibits tumor growth in pancreatic cancer
M Li, X Wang, W Li, F Li, H Yang, H Wang… - Cancer …, 2008 - Wiley Online Library
Functional somatostatin receptors (SSTR) are lost in human pancreatic cancer. Transfection
of SSTR‐1 inhibited pancreatic cancer cell proliferation in vitro. We hypothesize that stable …
of SSTR‐1 inhibited pancreatic cancer cell proliferation in vitro. We hypothesize that stable …
The antiproliferative effects of somatostatin receptor subtype 2 in breast cancer cells
Y He, X Yuan, P Lei, S Wu, W Xing, X Lan… - Acta Pharmacologica …, 2009 - nature.com
Aim: Somatostatin receptor subtype 2 (SSTR2) is the principal mediator of somatostatin's
(SST) antiproliferative effects on normal and cancer cells. Therefore, we investigated …
(SST) antiproliferative effects on normal and cancer cells. Therefore, we investigated …