[HTML][HTML] Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma
S Yang, C Luo, Q Gu, Q Xu, G Wang, H Sun, Z Qian… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the fifth most common type of cancers worldwide.
However, current therapeutic approaches for this epidemic disease are limited, and its 5 …
However, current therapeutic approaches for this epidemic disease are limited, and its 5 …
Exploring the JAK/STAT signaling pathway in hepatocellular carcinoma: unraveling signaling complexity and therapeutic implications
H Park, S Lee, J Lee, H Moon, SW Ro - International Journal of Molecular …, 2023 - mdpi.com
Hepatocellular Carcinoma (HCC) continues to pose a substantial global health challenge
due to its high incidence and limited therapeutic options. In recent years, the Janus Kinase …
due to its high incidence and limited therapeutic options. In recent years, the Janus Kinase …
JAK/STAT signaling in hepatocellular carcinoma
JJ Hin Tang, DK Hao Thng, JJ Lim, TB Toh - Hepatic oncology, 2020 - Taylor & Francis
Liver cancer is the second most lethal cancer in the world with limited treatment options.
Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has …
Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has …
Mechanisms and therapeutic prospect of the JAK-STAT signaling pathway in liver cancer
JJ Jia, X Zhou, Q Chu - Molecular and Cellular Biochemistry, 2024 - Springer
Liver cancer (LC) poses a significant global health challenge due to its high incidence and
poor prognosis. Current systemic treatment options, such as surgery, chemotherapy …
poor prognosis. Current systemic treatment options, such as surgery, chemotherapy …
Tumoricidal effects of the JAK inhibitor Ruxolitinib (INC424) on hepatocellular carcinoma in vitro
Hepatocellular carcinoma (HCC) is an aggressive tumour with limited treatment options. The
Janus kinase/signal transducers and activators of transcription (JAK/STAT) signalling …
Janus kinase/signal transducers and activators of transcription (JAK/STAT) signalling …
The effect of JAK2 knockout on inhibition of liver tumor growth by inducing apoptosis, autophagy and anti-proliferation via STATs and PI3K/AKT signaling pathways
Y Xu, SX Lv - Biomedicine & Pharmacotherapy, 2016 - Elsevier
Liver cancer is a leading cause of cancer death, making it as the second most common
cause for death from cancer globally. Though many studies before have explored a lot for …
cause for death from cancer globally. Though many studies before have explored a lot for …
[PDF][PDF] Mutational analysis of JAK1 gene in human hepatocellular carcinoma
W PaRK, S Nam - Neoplasma, 2009 - researchgate.net
The Janus kinase 1 (JaK1) gene encodes a cytoplasmic tyrosine kinase that is
noncovalently associated with a variety of cytokine receptors and plays a nonredundant role …
noncovalently associated with a variety of cytokine receptors and plays a nonredundant role …
Janus Kinase 2 (JAK2) dissociates hepatosteatosis from hepatocellular carcinoma in mice
SY Shi, CT Luk, SA Schroer, MJ Kim… - Journal of Biological …, 2017 - ASBMB
Hepatocellular carcinoma is an end-stage complication of non-alcoholic fatty liver disease
(NAFLD). Inflammation plays a critical role in the progression of non-alcoholic fatty liver …
(NAFLD). Inflammation plays a critical role in the progression of non-alcoholic fatty liver …
Jak-stat signaling induced by interleukin-6 family cytokines in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. It
can be caused by chronic liver cell injury with resulting sustained inflammation, eg, triggered …
can be caused by chronic liver cell injury with resulting sustained inflammation, eg, triggered …
Analysis of clinical significance and prospective molecular mechanism of main elements of the JAK/STAT pathway in hepatocellular carcinoma
X Wang, X Liao, T Yu, Y Gong… - International …, 2019 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is one the most common malignancies and has poor
prognosis in patients. The aim of the present study is to explore the clinical significance of …
prognosis in patients. The aim of the present study is to explore the clinical significance of …
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