Delivering the promise of miRNA cancer therapeutics

DM Pereira, PM Rodrigues, PM Borralho… - Drug discovery today, 2013 - Elsevier
MicroRNAs (miRNAs) are pivotal post-transcriptional gene expression regulators. These
endogenous small non-coding RNAs aberrantly expressed in cancer have significant roles …

Advances in the discovery of microRNA-based anticancer therapeutics: latest tools and developments

KKW To, W Fong, CWS Tong, M Wu… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that repress the
expression of their target genes by reducing mRNA stability and/or inhibiting translation …

In vivo delivery of miRNAs for cancer therapy: challenges and strategies

Y Chen, DY Gao, L Huang - Advanced drug delivery reviews, 2015 - Elsevier
Abstract MicroRNAs (miRNAs), small non-coding RNAs, can regulate post-transcriptional
gene expressions and silence a broad set of target genes. miRNAs, aberrantly expressed in …

[HTML][HTML] MicroRNAs and their big therapeutic impacts: delivery strategies for cancer intervention

C Holjencin, A Jakymiw - Cells, 2022 - mdpi.com
Three decades have passed from the initial discovery of a microRNA (miRNA) in
Caenorhabditis elegans to our current understanding that miRNAs play essential roles in …

Targeting microRNAs in cancer: rationale, strategies and challenges

R Garzon, G Marcucci, CM Croce - Nature reviews Drug discovery, 2010 - nature.com
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate
gene expression. Early studies have shown that miRNA expression is deregulated in cancer …

MicroRNAs as new therapeutic targets and tools in cancer

P Gandellini, V Profumo, M Folini… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: MicroRNAs (miRNAs) are a class of endogenous, non-coding small RNAs that
negatively regulate gene expression at the post-transcriptional level. Several studies have …

[HTML][HTML] Targeting miRNAs and other non-coding RNAs as a therapeutic approach: an update

E Bayraktar, R Bayraktar, H Oztatlici… - Non-coding RNA, 2023 - mdpi.com
Since the discovery of the first microRNAs (miRNAs, miRs), the understanding of miRNA
biology has expanded substantially. miRNAs are involved and described as master …

[HTML][HTML] Recent advances in miRNA delivery systems

I Dasgupta, A Chatterjee - Methods and protocols, 2021 - mdpi.com
MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that
are produced in a tissue and time-specific manner to orchestrate gene expression post …

MicroRNA-based therapeutics for cancer

V Wang, W Wu - BioDrugs, 2009 - Springer
MicroRNAs (miRNAs) are non-protein-coding small RNA molecules that negatively regulate
target messenger RNA through degradation or suppression of protein translation. MiRNAs …

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

R Rupaimoole, FJ Slack - Nature reviews Drug discovery, 2017 - nature.com
In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …