The adipose-derived hormone leptin is well known for its function in the control of energy
homeostasis. Recent studies suggest a novel role for this adipokine in the regulation of …

Objective: The mechanisms that underlie the association between abdominal obesity and
depression risk in older persons are not well known, but the “leptin hypothesis” of …

Leptin is an adipocyte-derived signal factor (167 amino acid protein) encoded by the ob
gene in chromosome 7q31 that regulates eating behaviour via central neuroendocrine …

BackgroundAbnormal regulation of the adipocyte-derived hormone leptin could play a role
in body weight gain induced by antipsychotics. AimsTo study the effects of long-term …

Leptin has been demonstrated to correlate with body fat content in humans, but the
regulation of leptin levels is poorly understood. Therefore, we studied the relation between …

Objective A reduction in circulating leptin has been reported in some patients with BN, but
not in others. The reasons for such diversity have not been explained. Therefore, we …

Testosterone levels are decreased in obese men but increased in obese women. The
interplay between gonadal steroids and leptin is, at present, far from being elucidated. This …

Aims Recent studies suggest that leptin may have an effect on emotion and mood. Low
levels of leptin in depression and anxiety have been reported in many animal models; …

Background: In depressed patients, overstimulation of the hypothalamo-pituitary-
adrenocortical (HPA) system, probably caused by glucocorticoid receptor resistance, is the …

Insulin is known to increase expression of the ob gene product leptin in adipose tissue of
rodents. We determined whether insulin increases circulating leptin concentrations in …