A critical appraisal of the premotor symptoms of Parkinson's disease: potential usefulness in early diagnosis and design of neuroprotective trials

AE Lang - Movement Disorders, 2011 - Wiley Online Library
The neurodegenerative process is well established in Parkinson patients presenting to a
physician with early motor signs. There is increasing evidence that a variety of nonmotor …

Progression of nonmotor symptoms in subgroups of patients with non–dopamine‐deficient Parkinsonism

S Taylor, J Gafton, B Shah, G Pagano… - Movement …, 2016 - Wiley Online Library
Background Ten to fifteen percent of Parkinson's disease (PD) patients recruited to clinical
trials have scans without evidence of dopaminergic deficit, whose presence represents a …

Evaluation of mild cognitive impairment subtypes in Parkinson's disease

BA Cholerton, CP Zabetian, JY Wan… - Movement …, 2014 - Wiley Online Library
Mild cognitive impairment in Parkinson's disease (PD‐MCI) is common and increases the
risk for dementia. Establishing distinct PD‐MCI cognitive subtypes could be valuable for …

Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease

B Post, D Muslimovic, N van Geloven… - Movement …, 2011 - Wiley Online Library
Objective: To determine progression and prognostic factors of progression rate of motor
impairment, disability, and quality of life (QoL) in patients with newly diagnosed Parkinson's …

Clinical diagnostic criteria for dementia associated with Parkinson's disease

M Emre, D Aarsland, R Brown, DJ Burn… - … : official journal of the …, 2007 - Wiley Online Library
Dementia has been increasingly more recognized to be a common feature in patients with
Parkinson's disease (PD), especially in old age. Specific criteria for the clinical diagnosis of …

Predictors of motor complications in early Parkinson's disease: A prospective cohort study

MJ Kelly, MA Lawton, F Baig, C Ruffmann… - Movement …, 2019 - Wiley Online Library
Objective The objective of this study was to identify clinical predictors of motor complications
(dyskinesia and motor fluctuations) of levodopa in a prospectively recruited PD cohort using …

Defining optimal cutoff scores for cognitive impairment using Movement Disorder Society Task Force criteria for mild cognitive impairment in Parkinson's disease

JG Goldman, S Holden, B Bernard… - Movement …, 2013 - Wiley Online Library
ABSTRACT The recently proposed Movement Disorder Society (MDS) Task Force
diagnostic criteria for mild cognitive impairment in Parkinson's disease (PD‐MCI) represent …

Nonmotor versus motor symptoms: how much do they matter to health status in Parkinson's disease?

C Hinnell, CS Hurt, S Landau, RG Brown… - Movement …, 2012 - Wiley Online Library
Evidence suggests that both motor and nonmotor symptoms contribute to health status in
Parkinson's disease. Less clear is how much change in health status can be expected if …

Impact of depression on progression of impairment and disability in early Parkinson's disease

D Bega, S Luo, H Fernandez, K Chou… - Movement disorders …, 2015 - Wiley Online Library
Background Depression is one of the most common nonmotor symptoms associated with
Parkinson's disease (PD), yet the impact of depression on progression of disease is unclear …

The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease

P Barone, A Antonini, C Colosimo… - … : official journal of the …, 2009 - Wiley Online Library
We performed a multicenter survey using a semistructured interview in 1,072 consecutive
patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to …