An important number of patients with Acute Myeloid Leukemia (AML) experience relapse or
resistance to chemotherapy. One of the mechanisms involved in this resistance is the …

In an attempt to determine the incidence and clinical relevance of mdr1 gene expression in
acute myeloid leukemia (AML), we examined 126 specimens obtained from adult patients …

The Multidrug Resistance gene (MDR 1) is frequently expressed in acute myeloid leukaemia
(AML). MDR 1 is associated with resistance to chemotherapy in vitro and with a poor …

Resistance to cytotoxic agents may be encountered during the treatment of acute
myeloblastic leukaemia (AML). P-glycoprotein encoded by the MDR-1 gene has been …

We have compared the prognostic value of MDR1 RNA expression with that of other clinical
parameters in 63 patients with acute myeloid leukemia. MDR1 RNA expression of the …

Resistance to chemotherapy is one of the major obstacles to effective treatment in acute
myeloid leukemia (AML). The most extensively studied protein involved in multidrug …

Up till now, clinical data on the possible prognostic influence of multidrug resistance (MDR)
in hematological malignancies have been inconsistent, probably due to technical pitfalls …

In order to further define the role of the MDR1 gene in acute myeloid leukemia (AML), we
determined the association between the presence of P-glycoprotein on leukemic cells and …

Acute myeloid leukemia (AML) has a poor long-term prognosis, with a disease-free survival
rate of only 20%. Drug resistance remains the major obstacle in this disease, although …

The MDR1 gene is of prognostic significance in acute myeloid leukemia (AML). The
relationship of this gene to surface markers largely remains unclear. Therefore, we have …