CD11c+ dendritic cells (DCs) are a prominent component of CNS infiltrates in mice with
experimental autoimmune encephalomyelitis. However, their role in immunopathogenesis is …

CD8+ T cell depletion renders CD28-deficient mice susceptible to experimental autoimmune
encephalomyelitis (EAE). In addition, CD8–/–CD28–/–double-knockout mice are susceptible …

Counter-balancing regulatory mechanisms, such as the induction of regulatory T cells
(Treg), limit the effects of autoimmune attack in neuroinflammation. However, the role of …

The origin and function of CD20+ T cells are poorly understood. Here, we characterized
CD20+ T cells in mice and humans and investigated how they are affected by anti-CD20 …

Chronic progression of relapsing experimental autoimmune encephalomyelitis (R‐EAE), a
mouse model of multiple sclerosis (MS), is dependent on the activation of T cells to …

Abstract IL-17-and IFN-γ-secreting T cells play an important role in autoimmune responses
in multiple sclerosis and the model system experimental autoimmune encephalomyelitis …

Autoreactive CD4+ T cells exist in normal individuals and retain the capacity to initiate
autoimmune disease. The current study investigates the role of CD4+ CD25+ T-regulatory …

Myeloid-derived suppressor cells (MDSCs) are a diverse group of cells that are recognized
for their remarkable suppressive effects on pro-inflammatory T cells. The pleiotropic nature …

Plasmacytoid dendritic cells (pDCs) have both stimulatory and regulatory effects on T cells.
pDCs are a major CNS-infiltrating dendritic cell population during experimental autoimmune …

In chronically inflamed tissues, such as those affected by autoimmune disease, activated Th
cells often colocalize with monocytes. We investigate in this study how murine Th cells …