Role of JNK activation and mitochondrial Bax translocation in allicin‐induced apoptosis in human ovarian cancer SKOV3 cells

L Xu, J Yu, D Zhai, D Zhang, W Shen… - Evidence‐based …, 2014 - Wiley Online Library
Background. Allicin, the major component of freshly crushed garlic, is one of the most
biologically active compounds of garlic; it has been reported to induce apoptosis in cancer …

Role of p38 MAPK activation and mitochondrial cytochrome-c release in allicin-induced apoptosis in SK-N-SH cells

J Zhuang, Y Li, Y Chi - Anti-Cancer Drugs, 2016 - journals.lww.com
Here, we investigate the apoptotic effect of allicin, the predominant component of freshly
crushed garlic, on neuroblastoma cells. In this paper, the authors have first assessed the …

Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways

W Zhang, M Ha, Y Gong, Y Xu… - Oncology …, 2010 - spandidos-publications.com
Allicin is an active compound derived from garlic that has been shown to have antitumor
properties in vitro. The current study was designed to explore the effects and the underlying …

Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway

JH Cha, YJ Choi, SH Cha, CH Choi… - Oncology …, 2012 - spandidos-publications.com
Allicin, the main flavor compound in garlic, has anti-carcinogenic activities in a range of
cancer cells, however, the underlying molecular mechanisms are not completely …

[HTML][HTML] Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway

X Zhang, Y Zhu, W Duan… - Molecular medicine …, 2015 - spandidos-publications.com
Gastric cancer is one of the most common forms of malignant tumor, and the development of
anti‑gastric cancer drugs with minimal toxicity is of clinical importance. Allicin is extracted …

Allicin induces apoptosis in EL-4 cells in vitro by activation of expression of caspase-3 and -12 and up-regulation of the ratio of Bax/Bcl-2

Z Wang, Z Liu, Z Cao, L Li - Natural product research, 2012 - Taylor & Francis
Garlic (Allium sativum L.; Liliaceae) has been widely demonstrated in the role of cancer
prevention, but the specific compound in garlic corresponding to this effect and its …

Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells

S Oommen, RJ Anto, G Srinivas… - European journal of …, 2004 - Elsevier
Garlic (Allium sativum) has been used for centuries for treating various ailments, and its
consumption is said to reduce cancer risk and its extracts and components effectively block …

[HTML][HTML] Allicin induces apoptosis through activation of both intrinsic and extrinsic pathways in glioma cells

C Li, H Jing, G Ma, P Liang - Molecular medicine …, 2018 - spandidos-publications.com
Allicin is an extract purified from Allium sativum (garlic), and previous research has indicated
that Allicin has an inhibitory effect on many kinds of tumor cells. The aim of the present study …

Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy

YL Chu, CT Ho, JG Chung, R Raghu… - Journal of agricultural …, 2013 - ACS Publications
Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer globally and
ranks first among the cancer-related mortalities in Taiwan. This study aims to understand the …

Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA

SY Park, SJ Cho, H Kwon, KR Lee, DK Rhee, S Pyo - Cancer Letters, 2005 - Elsevier
Allicin, the major component of Garlic (Allium sativum) was examined for the ability to induce
apoptosis and the mechanism of the induction of apoptosis in human epithelial carcinoma …