mTOR inhibition is beneficial in neurodegenerative disease models and its effects are often
attributable to the modulation of autophagy and anti-apoptosis. Here, we report a neglected …

Mitochondria play a central role in a plethora of processes related to the maintenance of
cellular homeostasis and genomic integrity. They contribute to preserving the optimal …

Mitochondria are essential for neuronal survival and mitochondrial dysfunction is a hallmark
of neurodegeneration. The loss in mitochondrial energy production, oxidative stress, and …

The mechanistic (or mammalian) target of rapamycin (mTOR) and the adenosine
monophosphate-activated protein kinase (AMPK) regulate cell survival and metabolism in …

Mitochondria are organelles that play a central role in processes related to cellular viability,
such as energy production, cell growth, cell death via apoptosis, and metabolism of reactive …

Mitochondria are best known for their role in ATP generation. However, studies over the past
two decades have shown that mitochondria do much more than that. Mitochondria regulate …

Compelling evidence indicates that the mammalian target of rapamycin (mTOR) signaling
pathway is involved in cellular senescence, organismal aging and age-dependent diseases …

The mammalian target of rapamycin (mTOR) is a key regulator of cell growth, autophagy,
translation, and survival. Dysregulation of mTOR signaling is associated with cancer …

Neurodegeneration in mitochondrial disorders is considered irreversible because of limited
metabolic plasticity in neurons, yet the cell-autonomous implications of mitochondrial …

The mammalian target of rapamycin (mTOR) was reported to regulate cell autophagy and
outcomes of several neurological diseases. Mitochondria, which serve as critical organelles …