ABSTRACT A hallmark of the mammalian immune system is its ability to respond efficiently
to foreign antigens without eliciting an inappropriate response to self-antigens. Furthermore …

The lymphatic network that transports interstitial fluid and antigens to lymph nodes
constitutes a conduit system that can be hijacked by invading pathogens to achieve systemic …

Secondary lymphoid tissues are the sites of both innate and adaptive host defense. Aside
from the relatively static nonhematopoietic stromal elements and some macrophages and …

Lymph nodes are secondary lymphoid organs in which immune responses of the adaptive
immune system are initiated and regulated. Distributed throughout the body and embedded …

The lymph node is a highly structured organ that mediates the body's adaptive immune
response to antigens and other foreign particles. Central to its function is the distinct spatial …

Anatomical strategies that help cells to interact greatly increase the efficiency of the adaptive
immune system. In vivo, antigens are presented in a complex environment, wherein their …

The lymph node is a highly organized and dynamic structure that is critical for facilitating the
intercellular interactions that constitute adaptive immunity. Most ex vivo studies of the lymph …

The lymph node (LN) is charged with a crucial function in the mammalian immune system: to
facilitate physical interactions between extremely rare cells arriving from different tissue …

Microanatomical organization of innate immune cells within lymph nodes (LNs) is critical for
the generation of adaptive responses. In particular, steady-state LN-resident dendritic cells …

The immune system is a multicentered organ that is characterized by intimate interactions
between its cellular components to efficiently ward off invading pathogens. A key constituent …