Polyglutamine (polyQ) diseases are inherited neurodegenerative disorders caused by the
expansion of CAG codon repeats, which code for polyQ in the corresponding gene products …

The basis of neuron-specific pathogenesis, resulting from the expression of misfolded
proteins, is poorly understood and of central importance to an understanding of the cell-type …

Two decades ago, molecular genetic analysis provided a new approach for defining the
roots of inherited disorders. This strategy has proved particularly powerful because, with …

Nine inherited neurodegenerative disorders result from polyglutamine expansions. Two
recently published papers on spinocerebellar ataxia type 1, together with studies on …

Proteins with expanded polyglutamine domains cause eight inherited neurodegenerative
diseases including Huntington's disease. In a previous paper, we identified peptides that …

Polyglutamine (polyQ) diseases represent a group of progressive neurodegenerative
disorders that are caused by abnormal expansion of CAG triplet nucleotides in disease …

Neurodegenerative polyglutamine (polyQ) disorders are caused by trinucleotide repeat
expansions within the coding region of disease-causing genes. PolyQ-expanded proteins …

In the past few years, a new type of genetic mutation, expansion of trinucleotide repeats, has
been shown to cause neurologic disease. This new class of mutations was first identified in …

Protein context clearly influences neurotoxicity in polyglutamine diseases, but the
contribution of alternative splicing to this phenomenon has rarely been investigated. Ataxin …

Polyglutamine (polyQ) diseases, resulting from a dynamic expansion of glutamine repeats in
a polypeptide, are a class of genetically inherited late onset neurodegenerative disorders …