The treatment of cancer has been one of the most significant challenges for the medical
field. Further research on the signal transduction pathway of tumor cells is driving the rapid …

Chemotherapeutic and cytotoxic drugs are widely used in the treatment of cancer. In spite of
the improvements in the life quality of patients, their effectiveness is compromised by several …

Cancer is one of the leading causes of death with a mortality rate of 12%. Although
significant progress has been achieved in cancer research, the effective treatment of cancer …

Background: In recent years, several small molecularly–targeted kinase inhibitors have
been tested in the clinic for the treatment of cancer. One category of these agents provides …

Cancer chemotherapy has been one of the major medical advances in the last few decades.
However, the drugs used for this therapy have a narrow therapeutic index, and often the …

Target therapies for the treatment of human cancers have revolutionized the concept of
oncological medicine. This type of therapeutic approach is directed to the inhibition of …

GLOBOCAN 2020 estimated more than 19.3 million new cases, and about 10 million
patients were deceased from cancer in 2020. Clinical manifestations showed that several …

Over the last ten years, several new and therapeutically relevant cancer drugs targeting
tyrosine kinase signaling pathways have been developed. Tyrosine kinase inhibitors (TKIs) …

Protein kinases are key regulators that govern complex cellular processes. Dysregulation of
kinase signaling is associated in many human diseases, particularly cancers and …

The old-fashioned anticancer approaches, aiming at arresting cancer cell proliferation
interfering with non-specific targets (eg DNA), have been replaced, in the last decades, by …