Nitric oxide (NO) is an intercellular signaling molecule; among its many and varied roles are
the control of blood flow and blood pressure via activation of the heme enzyme, soluble …

Nitric oxide (NO) and its derivative peroxynitrite (ONOO−) inhibit mitochondrial respiration by
distinct mechanisms. Low (nanomolar) concentrations of NO specifically inhibit cytochrome …

Mitochondria, the site of oxidative energy metabolism in eukariotic cells, are a highly
organised structure endowed with different enzymes and reactions localized in discrete …

Nitric oxide (NO) reversibly inhibits mitochondrial respiration by competing with oxygen at
cytochrome oxidase. Concentrations of NO measured in a range of biological systems are …

Nitric oxide (NO) and its derivatives inhibit mitochondrial respiration by a variety of means.
Nanomolar concentrations of NO immediately, specifically and reversibly inhibit cytochrome …

Nitric oxide (NO•) signaling is diverse, and involves reaction with free radicals,
metalloproteins, and specific protein amino acid residues. Prominent among these …

Nitric oxide (NO) at high levels is cytotoxic, and may be involved in a range of inflammatory,
neurodegenerative, and cardio-vascular/ischaemic pathologies. The mechanism of NO …

The biochemistry of the mitochondrial production of nitric oxide is reviewed to gain insight
into the basic role of this radical in mitochondrial and cellular oxidative metabolism. The …

Mitochondrial metabolism is essential for aerobic organisms and as such is a potential target
for the removal of either cancerous cells or parasites. The cell most frequently employed in …

Cell respiration is controlled by nitric oxide (NO) reacting with respiratory chain complexes,
particularly with Complex I and IV. The functional implication of these reactions is different …