Emerging findings suggest that compromised cellular bioenergetics and DNA repair
contribute to the pathogenesis of Alzheimer's disease (AD), but their role in disease-defining …

Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. Impaired
neuronal bioenergetics and neuroinflammation are thought to play key roles in the …

Mitochondria in neurons generate adenosine triphosphate (ATP) to provide the necessary
energy required for constant activity. Nicotinamide adenine dinucleotide (NAD+) is a vital …

Background Mitochondrial dysfunction is a hallmark of neurodegenerative diseases
including Alzheimer's disease (AD), with morphological and functional abnormalities limiting …

Background and Purpose—NAD+ is an essential cofactor for cellular energy production and
participates in various signaling pathways that have an impact on cell survival. After cerebral …

Alzheimer's disease (AD) is an incurable neurodegenerative disease that is more prevalent
in women. The increased risk of AD in women is not well understood. It is well established …

DNA repair ensures genomic stability to achieve healthy ageing, including cognitive
maintenance. Mutations on genes encoding key DNA repair proteins can lead to diseases …

Background The role of mitochondrial dysfunction has long been implicated in age-related
brain pathology, including Alzheimer's disease (AD). However, the mechanism by which …

Oxidative DNA damage is implicated in brain aging, neurodegeneration and neurological
diseases. Damage can be created by normal cellular metabolism, which accumulates with …

The brain depends on redox electrons from nicotinamide adenine dinucleotide (reduced
form; NADH) to produce ATP and oxyradicals (reactive oxygen species [ROS]). Because …