Gallstone disease is a common complex disease that confers a substantial economic
burden on society. The genetic underpinnings of gallstone disease remain incompletely …

Background & Aims A genome-wide association study (GWAS) of 280 cases identified the
hepatic cholesterol transporter ABCG8 as a locus associated with risk for gallstone disease …

Abstract Background and Aims Genome‐wide association studies (GWAS) have identified
several risk loci for gallstone disease. As with most polygenic traits, it is likely that many …

Background Gallstone disease is one of the most common digestive disorders, affecting
more than 30 million Americans. Previous twin studies suggest a heritability of 25% for …

Gallstones are responsible for one of the most common diseases in the Western world and
are commonly treated with cholecystectomy. We perform a meta-analysis of two genome …

Background & Aims Obesity, type 2 diabetes, and lifestyle factors (cigarette smoking, alcohol
drinking, and coffee consumption) have been associated with the risk of developing …

With an overall prevalence of 10-20%, gallstone disease (cholelithiasis) represents one of
the most frequent and economically relevant health problems of industrialized countries. We …

BACKGROUND & AIMS: Genome-wide association studies have mapped loci that are
associated with serum levels of bilirubin. Bilirubin is a major component of gallstones so we …

Objectives Gallstone disease (cholelithiasis) has a familial component, but detailed data on
the modification of familial risk are lacking. Using nationwide hospital and population …

Background & Aims Adiposity has been consistently associated with gallstone disease risk.
We aimed to characterize associations of anthropometric measures (body mass index [BMI] …