[PDF][PDF] Identification and replication of six loci associated with gallstone disease
H Gellert‐Kristensen, N Dalila… - …, 2019 - Wiley Online Library
Gallstone disease is a common complex disease that confers a substantial economic
burden on society. The genetic underpinnings of gallstone disease remain incompletely …
burden on society. The genetic underpinnings of gallstone disease remain incompletely …
Four susceptibility loci for gallstone disease identified in a meta-analysis of genome-wide association studies
Background & Aims A genome-wide association study (GWAS) of 280 cases identified the
hepatic cholesterol transporter ABCG8 as a locus associated with risk for gallstone disease …
hepatic cholesterol transporter ABCG8 as a locus associated with risk for gallstone disease …
[PDF][PDF] Genome‐wide analysis identifies gallstone‐susceptibility loci including genes regulating gastrointestinal motility
Abstract Background and Aims Genome‐wide association studies (GWAS) have identified
several risk loci for gallstone disease. As with most polygenic traits, it is likely that many …
several risk loci for gallstone disease. As with most polygenic traits, it is likely that many …
Lipid trait-associated genetic variation is associated with gallstone disease in the diverse Third National Health and Nutrition Examination Survey (NHANES III)
R Goodloe, K Brown-Gentry, NB Gillani, H Jin… - BMC Medical …, 2013 - Springer
Background Gallstone disease is one of the most common digestive disorders, affecting
more than 30 million Americans. Previous twin studies suggest a heritability of 25% for …
more than 30 million Americans. Previous twin studies suggest a heritability of 25% for …
Genome-wide association meta-analysis yields 20 loci associated with gallstone disease
Gallstones are responsible for one of the most common diseases in the Western world and
are commonly treated with cholecystectomy. We perform a meta-analysis of two genome …
are commonly treated with cholecystectomy. We perform a meta-analysis of two genome …
[HTML][HTML] Obesity, type 2 diabetes, lifestyle factors, and risk of gallstone disease: a Mendelian randomization investigation
Background & Aims Obesity, type 2 diabetes, and lifestyle factors (cigarette smoking, alcohol
drinking, and coffee consumption) have been associated with the risk of developing …
drinking, and coffee consumption) have been associated with the risk of developing …
[PDF][PDF] Genomewide genetic association studies in hepatology: the end of searching for the needle in the haystack?
C Hellerbrand, HE Wasmuth - Hepatology, 2007 - Wiley Online Library
With an overall prevalence of 10-20%, gallstone disease (cholelithiasis) represents one of
the most frequent and economically relevant health problems of industrialized countries. We …
the most frequent and economically relevant health problems of industrialized countries. We …
Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition
S Buch, C Schafmayer, H Völzke, M Seeger, JF Miquel… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Genome-wide association studies have mapped loci that are
associated with serum levels of bilirubin. Bilirubin is a major component of gallstones so we …
associated with serum levels of bilirubin. Bilirubin is a major component of gallstones so we …
Familial risks for gallstones in the population of Sweden
K Hemminki, O Hemminki, A Försti… - BMJ open …, 2017 - bmjopengastro.bmj.com
Objectives Gallstone disease (cholelithiasis) has a familial component, but detailed data on
the modification of familial risk are lacking. Using nationwide hospital and population …
the modification of familial risk are lacking. Using nationwide hospital and population …
Obesity, adiposity, and risk of symptomatic gallstone disease according to genetic susceptibility
Background & Aims Adiposity has been consistently associated with gallstone disease risk.
We aimed to characterize associations of anthropometric measures (body mass index [BMI] …
We aimed to characterize associations of anthropometric measures (body mass index [BMI] …