Cystic fibrosis (CF) is an inherited disorder caused by a deleterious mutation in the cystic
fibrosis transmembrane conductance regulator (CFTR) gene. Given that the CFTR protein is …

Electronic cigarettes (e-cigs) are often promoted as safe alternatives to smoking based on
the faulty perception that inhaling nicotine is safe until other harmful chemicals in cigarette …

In patients with cystic fibrosis (CF), it is extraordinary that defects in a chloride channel
scarcely expressed in airway epithelia, produce severe bronchial infections and eventually …

Lung health relies on effective mucociliary clearance and innate immune defence
mechanisms. In cystic fibrosis (CF), an imbalance in ion transport due to an absence of …

Sinonasal respiratory epithelium is a highly regulated barrier that employs mucociliary
clearance (MCC) as the airways first line of defense. The biological properties of the airway …

Cystic fibrosis (CF) is a mucoobstructive pathology associated with chronic inflammation and
chronic bacterial infection of the lungs. Mutations in the CF gene lead to dysfunction of the …

Question Cystic fibrosis (CF) is characterised by the accumulation of viscous adherent
mucus in the lungs. While several hypotheses invoke a direct relationship with cystic fibrosis …

Our current understanding of the pathogenesis of cystic fibrosis (CF) lung disease stresses
the importance of the physical and chemical properties of the airway surface liquid (ASL). In …

Cystic fibrosis (CF) is an autosomal recessive disease that is caused by mutations in the
cystic fibrosis conductance regulator (CFTR) gene and usually presents with multiorgan …

Although there has been impressive progress in the elucidation of the genetic and molecular
basis of cystic fibrosis (CF), the pathogenesis of CF lung disease remains obscure. The …