Current antiangiogenic therapy is limited by its cytostatic property, scarce drug delivery to
the tumor, and side toxicity. To address these limitations, we unveiled the role of ZEB1, a …

Increased expression of zinc finger E-box binding homeobox 1 (ZEB1) is associated with
tumor grade and metastasis in lung cancer, likely due to its role as a transcription factor in …

Colorectal cancer remains the most common cause of cancer-related deaths worldwide and
it continues to lack an effective treatment. Here, we found that zinc finger E-box binding …

Simple Summary Given the importance of the epithelial-to-mesenchymal transition in tumor
progression and the pivotal role of ZEB1 as a transcriptional repressor during this process …

Although zinc finger E-box binding homeobox 1 (ZEB1) has been identified as a key factor in
the regulation of breast cancer differentiation and metastasis, its potential role in modulating …

Background The efficacy of immunotherapies in metastatic melanoma depends on a robust
T cell infiltration. Oncogenic alterations of tumor cells have been associated to T cell …

The transcription factor zinc finger E-box binding homeobox 1 (ZEB1) is a critical inducer of
epithelial mesenchymal transformation (EMT) and plays a robust role in tumor metastasis. It …

Diffuse invasion of the surrounding brain parenchyma is a major obstacle in the treatment of
gliomas with various therapeutics, including anti-angiogenic agents. Here we identify the epi …

Highly expressed Zinc-finger E-box binding protein 1 (ZEB1) is significantly associated with
the malignancy of various cancers. Signal transduction and activation of ZEB1 play …

Background ZEB2 is a transcriptional repressor that regulates epithelial-to-mesenchymal
transition (EMT) through binding to bipartite E-box motifs in gene regulatory regions. Despite …