The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers

NS Spoelstra, NG Manning, Y Higashi, D Darling… - Cancer research, 2006 - AACR
The transcription factor ZEB1 (δEF1 in mice) has been implicated in cellular processes
during development and tumor progression including epithelial to mesenchymal transition …

Zeb1 induces immune checkpoints to form an immunosuppressive envelope around invading cancer cells

Y Guo, X Lu, Y Chen, B Rendon, RA Mitchell… - Science …, 2021 - science.org
The PDL1-PD1 immune checkpoint inhibits T cell activation, and its blockade is effective in a
subset of patients. Studies are investigating how checkpoints are hijacked by cancer cells …

[HTML][HTML] ZEB1 promotes oxaliplatin resistance through the induction of epithelial-mesenchymal transition in colon cancer cells

C Guo, J Ma, G Deng, Y Qu, L Yin, Y Li, Y Han… - Journal of …, 2017 - ncbi.nlm.nih.gov
Background: Oxaliplatin (OXA) chemotherapy is widely used in the clinical treatment of
colon cancer. However, chemo-resistance is still a barrier to effective chemotherapy in cases …

[HTML][HTML] The curious case of ZEB1

M Madany, T Thomas, LA Edwards - Discoveries, 2018 - ncbi.nlm.nih.gov
Abstract The Zinc Finger E-box binding homeobox (ZEB1/TCF8 or DeltaEF1) is at the
forefront of transcription factors involved in controlling epithelial-to-mesenchymal transitions …

[HTML][HTML] Prognostic significance of zinc finger E-box-binding homeobox family in glioblastoma

P Chen, H Liu, A Hou, X Sun, B Li, J Niu… - Medical Science Monitor …, 2018 - ncbi.nlm.nih.gov
Background Epithelial-mesenchymal transition (EMT) is an essential progress for tumor cell
invasion to both epithelial and non-epithelial cancers, and zinc finger E-box-binding …

ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells

JM Drake, G Strohbehn, TB Bair… - Molecular biology of …, 2009 - Am Soc Cell Biol
Metastatic colonization involves cancer cell lodgment or adherence in the microvasculature
and subsequent migration of those cells across the endothelium into a secondary organ site …

ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis

DH Peng, C Ungewiss, P Tong, LA Byers, J Wang… - Oncogene, 2017 - nature.com
Lung cancer is the leading cause of cancer-related deaths, primarily due to distant
metastatic disease. Metastatic lung cancer cells can undergo an epithelial-to-mesenchymal …

Overexpression of ZEB1 associated with metastasis and invasion in patients with gastric carcinoma

B Jia, H Liu, Q Kong, B Li - Molecular and cellular biochemistry, 2012 - Springer
The aim of this study was to investigate the expression of ZEB1 in gastric carcinoma, its
correlation with the clinicopathology of gastric carcinoma, and the role of ZEB1 in invasion …

ZEB1 promotes inflammation and progression towards inflammation-driven carcinoma through repression of the DNA repair glycosylase MPG in epithelial cells

O de Barrios, L Sanchez-Moral, M Cortés, C Ninfali… - Gut, 2019 - gut.bmj.com
Objective Chronic inflammation is a risk factor in colorectal cancer (CRC) and reactive
oxygen species (ROS) released by the inflamed stroma elicit DNA damage in epithelial …

[HTML][HTML] Downregulation of ZEB2-AS1 decreased tumor growth and metastasis in hepatocellular carcinoma

T Lan, L Chang, L Wu, Y Yuan - Molecular medicine …, 2016 - spandidos-publications.com
Hepatocellular carcinoma (HCC) remains one of the most common types of cancer
worldwide and prognosis remains poor. Previous studies have suggested that long non …