Protein nitration and nitrosylation by NO-donating aspirin in colon cancer cells: Relevance to its mechanism of action

JL Williams, P Ji, N Ouyang, L Kopelovich… - Experimental cell …, 2011 - Elsevier
Nitric oxide-donating aspirin (NO-ASA) is a promising agent for cancer prevention. Although
studied extensively, its molecular targets and mechanism of action are still unclear. S …

Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and β-catenin/T-cell factor signaling …

JL Williams, N Nath, J Chen, TR Hundley, J Gao… - Cancer research, 2003 - AACR
Nitric oxide (NO)-releasing aspirin (ASA), consisting of a traditional ASA molecule to which a
NO-donating moiety is covalently bound, is a promising colon cancer chemopreventive …

NO-donating aspirin inhibits the activation of NF-κB in human cancer cell lines and Min mice

JL Williams, P Ji, N Ouyang, X Liu, B Rigas - Carcinogenesis, 2008 - academic.oup.com
Nitric oxide-donating aspirin (NO-ASA) is a promising agent for the control of cancer, whose
mechanism of action remains unclear. NF-κB is an important signaling molecule in the …

NO-releasing NSAIDs suppress NF-κB signaling in vitro and in vivo through S-nitrosylation

M Chattopadhyay, S Goswami, DB Rodes, R Kodela… - Cancer letters, 2010 - Elsevier
NO-NSAIDs are promising anticancer drugs, comprising an NSAID, an NO-releasing moiety,
and a spacer linking them. Although the effect of NO-NSAIDs on a wide variety of signaling …

NO-donating aspirin inhibits both the expression and catalytic activity of inducible nitric oxide synthase in HT-29 human colon cancer cells

A Spiegel, TR Hundley, J Chen, J Gao… - Biochemical …, 2005 - Elsevier
Nitric oxide-releasing aspirin (NO-ASA) is emerging as a potentially important
chemopreventive agent against colon cancer. We examined in HT-29 human colon …

Molecular targets of nitric-oxide-donating aspirin in cancer

K Kashfi, B Rigas - Biochemical Society Transactions, 2005 - portlandpress.com
Nitric-oxide-donating aspirin (NO-ASA), consisting of ASA (aspirin) plus an-ONO2 moiety
linked to it via a molecular spacer, is a new drug for cancer prevention. NO-ASA seems to …

Nitric oxide-donating aspirin inhibits colon cancer cell growth via mitogen-activated protein kinase activation

TR Hundley, B Rigas - Journal of Pharmacology and Experimental …, 2006 - ASPET
Nitric oxide-donating aspirin (NO-aspirin), representing a new concept in the development of
more efficacious nonsteroidal anti-inflammatory drugs, consists of traditional aspirin bearing …

Nitric-oxide-donating NSAIDs as agents for cancer prevention

B Rigas, K Kashfi - Trends in Molecular Medicine, 2004 - cell.com
Nitric-oxide-donating nonsteroidal anti-inflammatory drugs (NO–NSAIDs), which consist of
an NSAID with an NO-donating moiety covalently attached to it, promise to contribute …

Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress

J Gao, X Liu, B Rigas - … of the National Academy of Sciences, 2005 - National Acad Sciences
Nitric oxide-donating aspirin (NO-ASA) is a promising chemoprevention agent against colon
cancer and other cancers. It consists of traditional ASA to which a NO-releasing moiety is …

Novel agents for cancer prevention based on nitric oxide

B Rigas - Biochemical Society Transactions, 2007 - portlandpress.com
NO (nitric oxide) biology has provided the impetus for the development of anticancer agents
based on their ability to release NO. NO-NSAIDs (NO-donating non-steroidal anti …