Hypoxia preconditioned mesenchymal stem cells improve vascular and skeletal muscle fiber regeneration after ischemia through a Wnt4-dependent pathway

L Leroux, B Descamps, NF Tojais, B Séguy, P Oses… - Molecular therapy, 2010 - cell.com
Mesenchymal stem cells (MSC) are multipotent postnatal stem cells, involved in the
treatment of ischemic vascular diseases. We investigate the ability of MSC, exposed to short …

Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells

I Rosová, M Dao, B Capoccia, D Link, JA Nolta - Stem cells, 2008 - academic.oup.com
Mesenchymal stem cells (MSC) are adult multipotent cells found in bone marrow, adipose
tissue, and other adult tissues. MSC have been shown to improve regeneration of injured …

Hypoxic preconditioning promotes the bioactivities of mesenchymal stem cells via the HIF-1α-GRP78-Akt axis

JH Lee, YM Yoon, SH Lee - International journal of molecular sciences, 2017 - mdpi.com
Mesenchymal stem cells (MSC) are ideal materials for stem cell-based therapy. As MSCs
reside in hypoxic microenvironments (low oxygen tension of 1% to 7%), several studies …

Enhancement of angiogenic effects by hypoxia‐preconditioned human umbilical cord‐derived mesenchymal stem cells in a mouse model of hindlimb ischemia

KH Han, AK Kim, MH Kim, DH Kim… - Cell biology …, 2016 - Wiley Online Library
It has been studied that mesenchymal stem cells (MSCs) have the capability to promote
angiogenesis. Furthermore, there is strong evidence that hypoxic conditions can enhance …

Hypoxia preconditioned human adipose derived mesenchymal stem cells enhance angiogenic potential via secretion of increased VEGF and bFGF

L Liu, J Gao, Y Yuan, Q Chang, Y Liao… - Cell biology …, 2013 - Wiley Online Library
Mesenchymal stem cells (MSCs) are adult multipotent cells found in bone marrow, adipose
tissue, and other adult tissues. MSCs improve regeneration of injured tissues in vivo, but the …

Hypoxia preconditioned bone marrow-derived mesenchymal stromal/stem cells enhance myoblast fusion and skeletal muscle regeneration

K Archacka, I Grabowska, B Mierzejewski… - Stem Cell Research & …, 2021 - Springer
Background The skeletal muscle reconstruction occurs thanks to unipotent stem cells, ie,
satellite cells. The satellite cells remain quiescent and localized between myofiber …

Hypoxia-preconditioned mesenchymal stem cells ameliorate ischemia/reperfusion-induced lung injury

YY Liu, CH Chiang, SC Hung, CF Chian, CL Tsai… - Plos one, 2017 - journals.plos.org
Background Hypoxia preconditioning has been proven to be an effective method to enhance
the therapeutic action of mesenchymal stem cells (MSCs). However, the beneficial effects of …

Hypoxia-inducible factor 1 alpha contributes to cardiac healing in mesenchymal stem cells-mediated cardiac repair

I Cerrada, A Ruiz-Saurí, R Carrero… - Stem cells and …, 2013 - liebertpub.com
Mesenchymal stem cells (MSC) are effective in treating myocardial infarction (MI) and
previous reports demonstrated that hypoxia improves MSC self-renewal and therapeutics …

Inducible metabolic adaptation promotes mesenchymal stem cell therapy for ischemia: a hypoxia-induced and glycogen-based energy prestorage strategy

H Zhu, A Sun, Y Zou, J Ge - Arteriosclerosis, thrombosis, and …, 2014 - Am Heart Assoc
Objective—Ischemic tissue is an environment with limited oxygen and nutrition availability.
The poor retention of mesenchymal stem cells (MSC) in ischemic tissues greatly limits their …

Hypoxia-preconditioned mesenchymal stem cells prevent renal fibrosis and inflammation in ischemia-reperfusion rats

N Ishiuchi, A Nakashima, S Doi, K Yoshida… - Stem cell research & …, 2020 - Springer
Abstract Background Mesenchymal stem cells (MSCs) have been reported to promote the
regeneration of injured tissue via their paracrine abilities, which are enhanced by hypoxic …