Genetic variants in major depressive disorder: from pathophysiology to therapy
In spite of promising preclinical results there is a decreasing number of new registered
medications in major depression. The main reason behind this fact is the lack of confirmation …
medications in major depression. The main reason behind this fact is the lack of confirmation …
Genetics and major depressive disorder: clinical implications for disease risk, prognosis and treatment
In the post-genomic era, genetics has led to limited clinical applications in the diagnosis and
treatment of major depressive disorder (MDD). Variants in genes coding for cytochrome …
treatment of major depressive disorder (MDD). Variants in genes coding for cytochrome …
Pharmacogenetics of major depressive disorder: top genes and pathways toward clinical applications
C Fabbri, A Serretti - Current psychiatry reports, 2015 - Springer
The pharmacogenetics of antidepressants has been not only a challenging but also
frustrating research field since its birth in the 1990s. Indeed, great expectations followed the …
frustrating research field since its birth in the 1990s. Indeed, great expectations followed the …
[HTML][HTML] Genetics of treatment outcomes in major depressive disorder: present and future
C Fabbri, A Serretti - Clinical Psychopharmacology and …, 2020 - ncbi.nlm.nih.gov
Pharmacogenetic testing is a useful and increasingly widespread tool to assist in
antidepressant prescription. More than ten antidepressants (including tricyclics, selective …
antidepressant prescription. More than ten antidepressants (including tricyclics, selective …
The role of genetics in the development and pharmacotherapy of depression and its impact on drug discovery
Complex disorders, such as depression, remain a mystery for scientists. Although genetic
factors are considered important for the prediction of one's vulnerability, it is hard to estimate …
factors are considered important for the prediction of one's vulnerability, it is hard to estimate …
Genetics of affective disorders
C Johansson, M Jansson, L Linnér, QP Yuan… - European …, 2001 - Elsevier
Despite substantial evidence for heritability in affective disorders the contributing genes
have proven elusive. Here we discuss the genetic epidemiology of depression, as well as …
have proven elusive. Here we discuss the genetic epidemiology of depression, as well as …
Genetics factors in major depression disease
M Shadrina, EA Bondarenko, PA Slominsky - Frontiers in psychiatry, 2018 - frontiersin.org
Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology.
According to the World Health Organization, about 350 million people in the world are …
According to the World Health Organization, about 350 million people in the world are …
[PDF][PDF] Pharmacogenetics of antidepressive drugs: a way towards personalized treatment of major depressive disorder
Major depressive disorder is one of the most prevalent psychiatric disorders, and in spite of
extensive ongoing research, we neither fully understand its etiopathological background …
extensive ongoing research, we neither fully understand its etiopathological background …
Progress and prospects in pharmacogenetics of antidepressant drugs
C Fabbri, C Crisafulli, M Calabrò, E Spina… - Expert Opinion on …, 2016 - Taylor & Francis
Introduction: Depression is responsible for the most part of the personal and socio-economic
burden due to psychiatric disorders. Since antidepressant response clusters in families …
burden due to psychiatric disorders. Since antidepressant response clusters in families …
New drug targets in the signaling pathways activated by antidepressants
M Páez-Pereda - Progress in Neuro-Psychopharmacology and …, 2005 - Elsevier
Studies of twins, genetic linkage and association support the existence of a genetic
component to the susceptibility to depression. Biochemical parameters that change in …
component to the susceptibility to depression. Biochemical parameters that change in …