In spite of promising preclinical results there is a decreasing number of new registered
medications in major depression. The main reason behind this fact is the lack of confirmation …

In the post-genomic era, genetics has led to limited clinical applications in the diagnosis and
treatment of major depressive disorder (MDD). Variants in genes coding for cytochrome …

The pharmacogenetics of antidepressants has been not only a challenging but also
frustrating research field since its birth in the 1990s. Indeed, great expectations followed the …

Pharmacogenetic testing is a useful and increasingly widespread tool to assist in
antidepressant prescription. More than ten antidepressants (including tricyclics, selective …

Complex disorders, such as depression, remain a mystery for scientists. Although genetic
factors are considered important for the prediction of one's vulnerability, it is hard to estimate …

Despite substantial evidence for heritability in affective disorders the contributing genes
have proven elusive. Here we discuss the genetic epidemiology of depression, as well as …

Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology.
According to the World Health Organization, about 350 million people in the world are …

Major depressive disorder is one of the most prevalent psychiatric disorders, and in spite of
extensive ongoing research, we neither fully understand its etiopathological background …

Introduction: Depression is responsible for the most part of the personal and socio-economic
burden due to psychiatric disorders. Since antidepressant response clusters in families …

Studies of twins, genetic linkage and association support the existence of a genetic
component to the susceptibility to depression. Biochemical parameters that change in …