Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders

LG Costa, TB Cole, K Dao, YC Chang, J Coburn… - Pharmacology & …, 2020 - Elsevier
Recent extensive evidence indicates that air pollution, in addition to causing respiratory and
cardiovascular diseases, may also negatively affect the brain and contribute to central …

Exposure to inhaled particulate matter activates early markers of oxidative stress, inflammation and unfolded protein response in rat striatum

R Guerra, E Vera-Aguilar, M Uribe-Ramirez, G Gookin… - Toxicology letters, 2013 - Elsevier
To study central nervous system airborne PM related subchronic toxicity, SD male rats were
exposed for eight weeks to either coarse (32 μg/m 3), fine (178 μg/m 3) or ultrafine (107 …

Air pollution particulate matter exposure and chronic cerebral hypoperfusion and measures of white matter injury in a murine model

Q Liu, K Shkirkova, K Lamorie-Foote… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Exposure to ambient air pollution particulate matter (PM) is associated with
increased risk of dementia and accelerated cognitive loss. Vascular contributions to …

Co-exposure to ambient PM2. 5 plus gaseous pollutants increases amyloid β1–42 accumulation in the hippocampus of male and female rats

SM Zarandi, A Shahsavani, F Khodagholi, Y Fakhri - Toxin reviews, 2021 - Taylor & Francis
Exposure to air pollution increases the risk of neurodegenerative disorders (ND) like
Alzheimer's disease (AD). The current in-vivo model study was undertaken to investigate the …

Air pollution and central nervous system disease: a review of the impact of fine particulate matter on neurological disorders

H Kim, WH Kim, YY Kim, HY Park - Frontiers in public health, 2020 - frontiersin.org
Background: It is widely known that the harmful effects of fine dust can cause various
diseases. Research on the correlation between fine dust and health has been mainly …

Atmospheric particulate matter aggravates CNS demyelination through involvement of TLR-4/NF-kB signaling and microglial activation

B Han, X Li, RS Ai, SY Deng, ZQ Ye, X Deng, W Ma… - Elife, 2022 - elifesciences.org
Abstract Atmospheric Particulate Matter (PM) is one of the leading environmental risk factors
for the global burden of disease. Increasing epidemiological studies demonstrated that PM …

[HTML][HTML] Ambient PM particles reach mouse brain, generate ultrastructural hallmarks of neuroinflammation, and stimulate amyloid deposition, tangles, and plaque …

S Hameed, J Zhao, RN Zare - Talanta Open, 2020 - Elsevier
Mice were exposed to ambient PM particles 8 h per day, 6 days per week, for twenty-four
weeks in enrichment chambers, with real-time mass concentration of PM 2.5 around 70 µg/m …

Effects of concentrated ambient ultrafine particulate matter on hallmarks of Alzheimer's disease in the 3xTgAD mouse model

D Herr, K Jew, C Wong, A Kennell, R Gelein… - Neurotoxicology, 2021 - Elsevier
Background Exposure to air pollution has been identified as a possible environmental
contributor to Alzheimer's Disease (AD) risk. As the number of people with AD worldwide …

Air pollution, ultrafine particles, and your brain: are combustion nanoparticle emissions and engineered nanoparticles causing preventable fatal neurodegenerative …

L Calderón-Garcidueñas, A Ayala - Environmental science & …, 2022 - ACS Publications
Exposure to particulate matter (PM) pollution damages the human brain. Fossil fuel burning
for transportation energy accounts for a significant fraction of urban air and climate pollution …

[HTML][HTML] Toxicity of urban air pollution particulate matter in developing and adult mouse brain: Comparison of total and filter-eluted nanoparticles

A Haghani, R Johnson, N Safi, H Zhang… - Environment …, 2020 - Elsevier
Air pollution (AirP) is associated with many neurodevelopmental and neurological disorders
in human populations. Rodent models show similar neurotoxic effects of AirP particulate …