We present a method for tissue fluorescence quantification in situ using a handheld fiber
optic probe that measures both the fluorescence and diffuse reflectance spectra. A simplified …

We report a dual-band normalization technique for in vivo quantification of the metabolic
biomarker, protoporphyrin IX (PpIX), during brain tumor resection procedures. The accuracy …

Object Accurate discrimination between tumor and normal tissue is crucial for optimal tumor
resection. Qualitative fluorescence of protoporphyrin IX (PpIX), synthesized endogenously …

Fluorescence diagnosis may be used to improve the safety and reliability of stereotactic
brain tumor biopsies using biopsy needles with integrated fiber optics. Based on 5 …

Protoporphyrin IX (PpIX) induced by 5-aminolevulinic acid (5-ALA) is increasingly used as a
fluorescent marker for fluorescence-guided resection of malignant gliomas. Understanding …

The fluorescence of protophorphyrin IX (PpIX) synthesized after incubation with 5-
aminolevulinic acid (5-Ala) is used for the intraoperative visualisation of glioma cells in vivo …

BACKGROUND Five-aminolevulinic acid (5-ALA) is well established for fluorescence-
guided resections of malignant gliomas by eliciting the accumulation of fluorescent …

Abstract Background and Objective The clinical usefulness of 5‐ALA guided detection of
tumor tissue has been demonstrated for a number of malignancies. However, current …

Fluorescence imaging in neurosurgery has a long historical development, with various
biomarkers and biochemical agents being used, and numerous technological approaches …

BACKGROUND Fluorescence-guided resections using 5-aminolevulinic acid (5-ALA)-
induced tumor porphyrins have been established as an adjunct for malignant glioma surgery …