Target identification, and optimization of dioxygenated amide derivatives as potent antibacterial agents with FabH inhibitory activity
H Chang, R Ji, Z Zhu, Y Wang, S Yan, D He… - European Journal of …, 2024 - Elsevier
The enzyme FabH plays a critical role in the initial step of fatty acid biosynthesis, which is
vital for the survival of bacteria. As a result, FabH has emerged as an appealing target for the …
vital for the survival of bacteria. As a result, FabH has emerged as an appealing target for the …
Novel Schiff‐Base‐Derived FabH Inhibitors with Dioxygenated Rings as Antibiotic Agents
Y Zhou, QR Du, J Sun, JR Li, F Fang, DD Li… - …, 2013 - Wiley Online Library
Fatty acid biosynthesis plays a vital role in bacterial survival and several key enzymes
involved in this biosynthetic pathway have been identified as attractive targets for the …
involved in this biosynthetic pathway have been identified as attractive targets for the …
Discovery of novel bacterial FabH inhibitors (Pyrazol-Benzimidazole amide derivatives): Design, synthesis, bioassay, molecular docking and crystal structure …
YT Wang, TQ Shi, J Fu, HL Zhu - European journal of medicinal chemistry, 2019 - Elsevier
The enzyme FabH catalyzes the initial step of fatty acid biosynthesis that is essential for
bacterial survival. Therefore, FabH has been identified as an attractive target for the …
bacterial survival. Therefore, FabH has been identified as an attractive target for the …
Study of acylhydrazone derivatives with deoxygenated seven-membered rings as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
Y Zhou, Y Luo, YS Yang, L Lu, HL Zhu - MedChemComm, 2016 - pubs.rsc.org
Fatty acid biosynthesis is essential for bacterial survival. FabH, β-ketoacyl-acyl carrier
protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation …
protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation …
Synthesis and Antimicrobial Activities of Oximes Derived from O‐Benzylhydroxylamine as FabH Inhibitors
Forty‐three oxime derivatives were synthesized by allowing O‐benzylhydroxylamines to
react with primary benzaldehydes or salicylaldehydes; these products were gauged as …
react with primary benzaldehydes or salicylaldehydes; these products were gauged as …
Design, synthesis and biological evaluation of urea derivatives from o-hydroxybenzylamines and phenylisocyanate as potential FabH inhibitors
ZL Li, QS Li, HJ Zhang, Y Hu, DD Zhu… - Bioorganic & medicinal …, 2011 - Elsevier
FabH, β-ketoacyl-acyl carrier protein (ACP) synthase III, is a particularly attractive target,
since it is central to the initiation of fatty acid biosynthesis and is highly conserved among …
since it is central to the initiation of fatty acid biosynthesis and is highly conserved among …
Novel FabH inhibitors: an updated article literature review (July 2012 to June 2013)
H Song, GZ Ao, HQ Li - Expert opinion on therapeutic patents, 2014 - Taylor & Francis
Introduction: Fatty acid biosynthesis is essential for the bacterial viability and growth. In
recent years, β-ketoacyl-acyl carrier protein synthase III (FabH) become an attractive new …
recent years, β-ketoacyl-acyl carrier protein synthase III (FabH) become an attractive new …
Design, synthesis and antibacterial activities of vanillic acylhydrazone derivatives as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
XL Wang, YB Zhang, JF Tang, YS Yang… - European journal of …, 2012 - Elsevier
Fatty acid biosynthesis is essential for bacterial survival. FabH, β-ketoacyl-acyl carrier
protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation …
protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation …
Design and synthesis of novel deoxybenzoin derivatives as FabH inhibitors and anti-inflammatory agents
HQ Li, Y Luo, PC Lv, L Shi, CH Liu, HL Zhu - Bioorganic & Medicinal …, 2010 - Elsevier
β-Ketoacyl-acyl carrier protein synthase III (FabH) catalyzes the initial step of fatty acid
biosynthesis via a type II fatty acid synthase in most bacteria. The important role of this …
biosynthesis via a type II fatty acid synthase in most bacteria. The important role of this …
Novel FabH inhibitors: a patent and article literature review (2000–2012)
Y Luo, YS Yang, J Fu, HL Zhu - Expert Opinion on Therapeutic …, 2012 - Taylor & Francis
Introduction: The traditional antimicrobial chemotherapy drugs play their effects mostly via
bacterial interference with in vivo amino acids, nucleotides, amino sugars and other small …
bacterial interference with in vivo amino acids, nucleotides, amino sugars and other small …
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