Application of global metabolomic profiling of synovial fluid for osteoarthritis biomarkers

AK Carlson, RA Rawle, E Adams… - Biochemical and …, 2018 - Elsevier
Osteoarthritis affects over 250 million individuals worldwide. Currently, there are no options
for early diagnosis of osteoarthritis, demonstrating the need for biomarker discovery. To find …

[PDF][PDF] Global metabolomic profiling of human synovial fluid for rheumatoid arthritis biomarkers

AK Carlson, RA Rawle, CW Wallace… - Clin Exp …, 2019 - clinexprheumatol.org
Global metabolomic profiling of human synovial fluid for rheumatoid arthritis biomarkers
Page 1 Clinical and Experimental Rheumatology 2019 Clinical and Experimental …

Characterization of synovial fluid metabolomic phenotypes of cartilage morphological changes associated with osteoarthritis

AK Carlson, RA Rawle, CW Wallace, EG Brooks… - Osteoarthritis and …, 2019 - Elsevier
Objective Osteoarthritis (OA) is a multifactorial disease with etiological heterogeneity. The
objective of this study was to classify OA subgroups by generating metabolomic phenotypes …

Utilizing metabolomics to identify potential biomarkers and perturbed metabolic pathways in osteoarthritis: A systematic review

PM Van Pevenage, JT Birchmier, RK June - Seminars in arthritis and …, 2023 - Elsevier
Purpose Osteoarthritis (OA) is a joint disease that is clinically diagnosed using components
of history, physical exam, and characteristic radiographic findings, such as joint space …

1H NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints

JR Anderson, S Chokesuwattanaskul… - Journal of proteome …, 2018 - ACS Publications
Despite osteoarthritis (OA) and rheumatoid arthritis (RA) being typically age-related, their
underlying etiologies are markedly different. We used 1H nuclear magnetic resonance …

The metabolome and osteoarthritis: possible contributions to symptoms and pathology

JS Rockel, M Kapoor - Metabolites, 2018 - mdpi.com
Osteoarthritis (OA) is a progressive, deteriorative disease of articular joints. Although
traditionally viewed as a local pathology, biomarker exploration has shown that systemic …

Global metabolite profiling of synovial fluid for the specific diagnosis of rheumatoid arthritis from other inflammatory arthritis

S Kim, J Hwang, J Xuan, YH Jung, HS Cha, KH Kim - PloS one, 2014 - journals.plos.org
Currently, reliable biomarkers that can be used to distinguish rheumatoid arthritis (RA) from
other inflammatory diseases are unavailable. To find possible distinctive metabolic patterns …

Metabolic analysis of knee synovial fluid as a potential diagnostic approach for osteoarthritis

B Mickiewicz, JJ Kelly, TE Ludwig… - Journal of …, 2015 - Wiley Online Library
Osteoarthritis (OA) is a leading cause of chronic joint pain in the older human population.
Diagnosis of OA at an earlier stage may enable the development of new treatments to one …

Global and targeted metabolomics of synovial fluid discovers special osteoarthritis metabolites

K Zheng, N Shen, H Chen, S Ni, T Zhang… - Journal of …, 2017 - Wiley Online Library
To identify special metabolites in synovial fluid of osteoarthritis (OA) via a metabolomics
approach. Synovial fluid of 35 participants (25 OA patients and 10 controls) was detected by …

Application of metabolomics to osteoarthritis: from basic science to the clinical approach

SAA Showiheen, ARJ Sun, X Wu, R Crawford… - Current rheumatology …, 2019 - Springer
Abstract Purpose of the Review Osteoarthritis (OA) is a multifactorial and progressive
disease affecting whole synovial joint. The extract pathogenic mechanisms and diagnostic …