Capsaicin depolarizes primary afferent C-fibers releasing substance P (SP) whose N-
terminal metabolites appear to play a role in the development of antinociception. Because …

Zinc is concentrated in the dorsal horn of the spinal cord and has been proposed to alter
excitability of primary afferent C-fibers, structures believed to be important in nociceptive …

Substance P (SP) is released from primary afferent fibers in response to nociceptive stimuli.
Capsaicin, which produces an initial hyperalgesic response followed by persistent …

We have studied the effects of capsaicin, administered at concentrations found to be
antinociceptive in behavioural tests, on nociceptive responses evoked both in spinal dorsal …

Capsaicin in the adult animal is believed to evoke a massive release of substance P (SP)
and a subsequent loss of primary afferent C-fiber activity. Given the antinociceptive effect of …

Capsaicin is currently used as a specific pharmacological tool for investigation of functions
of primary afferent C-fibres. Their peripheral terminals play an important role in “neurogenic …

Capsaicin and its analog, dihydrocapsaicin, produced chemogenic and thermal
antinociception and depletion of substance P from the dorsal spinal cord and dorsal root …

Capsaicin has been shown to evoke the release of substance P (SP) from small diameter
primary afferent fibers. Using an in vivo perfusion of the rat spinal cord, this study examined …

We have studied the effect of NE 19550 (olvanil, N-(4-hydroxy-3-methoxyphenyl) methyl-9Z-
octadecenamide), a capsaicin analogue with approximately equipotent antinociceptive …

The presence of the peptide substance P in small unmyelinated primary sensory neurons 5
appears to be related to the transmission of nociceptive impulses at the level of the spinal …