Capsaicin, 8-methyl-N-vanillyl-6-nonenamide, is the pungent algesic substance of the red
pepper. On local or systemic injection capsaicin causes a marked stimulation of peripheral …

Data obtained from neonatally treated rats are fairly consistent. However, there is
disagreement as to whether mechanical and thermal nociceptive thresholds are elevated or …

Calcitonin gene-related peptide (CGRP), which has been shown to modulate calcium in
both the brain and in peripheral tissues, has not previously been shown to modulate calcium …

Glutamate (Glu) is involved in excitatory neurotransmission and nociception and plays an
essential role in relaying noxious stimuli in the spinal cord. Intrathecal or epidural injection of …

In vitro. Release of adenosine from spinal cord synaptosomes was studied as described
previously(Sweeney et ci., 1987b). Briefly, male Sprague-Dawley rats, 250 to 300 g …

BACKGROUND: Lumbar intrathecal injection of oxytocin produces antinociception in rats
and analgesia in humans. Classically, oxytocin receptors couple to stimulatory G proteins …

Previous research has demonstrated that substance P N-terminal fragments produced by
the action of several different enzymes in the spinal cord could reduce nociception when …

Intrathecal Capsaicin Depletes Substance P in the Rat Spinal Cord and Produces
Prolonged Thermal Analgesia Page 1 platelet MAO activity reflects monoaminergic activity …

The effect of systemic zinc administration on the inflammatory hyperalgesia induced by
intraplantar injections of either complete Freund's adjuvant (CFA) or bacterial endotoxin …

Substance P (SP) N-terminal fragments are known to alter nociception when injected
intrathecally or when released in response to capsaicin. However, it is not known whether a …