Basic, Translational and Clinical Relevance of the DNA Repair and Redox Signaling Protein APE1 in Human Diseases
MR KELLEY - DNA Damage, DNA Repair and Disease Volume 2, 2020 - books.google.com
Apurinic/apyrimidinic endonuclease–reduction/oxidation factor 1 (APE1/ref. 1, also called
APE1) is a multifunctional enzyme with essential tasks in DNA repair and …
APE1) is a multifunctional enzyme with essential tasks in DNA repair and …
Basic, translational and clinical relevance of the DNA repair and redox signaling protein APE1 in human diseases
Apurinic/apyrimidinic endonuclease–reduction/oxidation factor 1 (APE1/ref. 1, also called
APE1) is a multifunctional enzyme with essential tasks in DNA repair and …
APE1) is a multifunctional enzyme with essential tasks in DNA repair and …
The multifunctional APE1 DNA repair–redox signaling protein as a drug target in human disease
RA Caston, S Gampala, L Armstrong… - Drug Discovery …, 2021 - Elsevier
Highlights•APE1 protein repairs small base lesions in the DNA base excision repair
pathway.•APE1 converts oxidized inactive transcription factors to a reduced and active …
pathway.•APE1 converts oxidized inactive transcription factors to a reduced and active …
[PDF][PDF] Knockout and Inhibition of Ape1: Roles of Ape1 in Base Excision DNA Repair and Modulation of Gene Expression. Antioxidants 2022, 11, 1817
Apurinic/apyrimidinic endonuclease 1/redox effector-1 (Ape1/Ref-1) is the major
apurinic/apyrimidinic (AP) endonuclease in mammalian cells. It functions mainly in the base …
apurinic/apyrimidinic (AP) endonuclease in mammalian cells. It functions mainly in the base …
Knockout and inhibition of Ape1: roles of Ape1 in base excision DNA repair and modulation of gene expression
Apurinic/apyrimidinic endonuclease 1/redox effector-1 (Ape1/Ref-1) is the major
apurinic/apyrimidinic (AP) endonuclease in mammalian cells. It functions mainly in the base …
apurinic/apyrimidinic (AP) endonuclease in mammalian cells. It functions mainly in the base …
[HTML][HTML] APE1/Ref-1–one target with multiple indications: emerging aspects and new directions
In the realm of DNA repair, base excision repair (BER) protein, APE1/Ref-1
(Apurinic/Apyrimidinic Endonuclease 1/Redox Effector-1, also called APE1) has been …
(Apurinic/Apyrimidinic Endonuclease 1/Redox Effector-1, also called APE1) has been …
Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment
The apurinic endonuclease 1/redox factor-1 (APE1) has a crucial function in DNA repair and
in redox signaling in mammals, and recent studies identify it as an excellent target for …
in redox signaling in mammals, and recent studies identify it as an excellent target for …
Going ape as an approach to cancer therapeutics
The DNA base excision repair (BER) pathway repairs alkylation and oxidative DNA damage
caused by endogenous and exogenous agents, including chemotherapeutic agents. Upon …
caused by endogenous and exogenous agents, including chemotherapeutic agents. Upon …
Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1
M Luo, S Delaplane, A Jiang, A Reed, Y He… - Antioxidants & redox …, 2008 - liebertpub.com
The DNA base excision-repair pathway is responsible for the repair of DNA damage caused
by oxidation/alkylation and protects cells against the effects of endogenous and exogenous …
by oxidation/alkylation and protects cells against the effects of endogenous and exogenous …
The APE1/REF-1 and the hallmarks of cancer
PB Siqueira, MM de Sousa Rodrigues… - Molecular Biology …, 2024 - Springer
Abstract APE1/REF-1 (apurinic/apyrimidinic endonuclease 1/redox factor-1) is a protein with
two domains, with endonuclease function and redox activity. Its main activity described is …
two domains, with endonuclease function and redox activity. Its main activity described is …