Angiotensin II (ANG II; 10 or 30 ng/min iv) was infused for 7-10 days in unilaterally
adrenalectomized and nephrectomized Sprague-Dawley rats drinking 1% NaCl. The acute …

There is increasing evidence that a major site of production of angiotensin I and II is
peripheral tissue. Both angiotensin I and II are present in venous blood in amounts far too …

A decline in the function of the renin angiotensin aldosterone system may induce adaptive
changes in response to angiotensin II (ANG II) with age. We have examined platelet ANG II …

The global pattern of illness has become increasingly similar, with a progressive shift to
morbidity and mortality from chronic diseases. Cardiovascular disease (CVD) is the leading …

We have previously described a subset of subjects with essential hypertension who fail to
appropriately modulate renal vascular and adrenal reactivity with changes in dietary sodium …

The Modification of Diet in Renal Disease Study was a multicenter trial of the effect of protein
restriction and strict blood pressure control on the progression rate of chronic renal failure of …

In 40-50% of patients with essential hypertension, a high sodium intake does not increase
renal blood flow (RBF). These patients have been defined as nonmodulators because …

Background: Hypertension becomes increasingly prevalent after menopause.
Postmenopausal women are more responsive to salt than premenopausal women, and they …

Abnormal renovascular resistance and glomerular filtration rate are characteristic of
established hypertension and may also be involved in its pathogenesis. To determine renal …

Background: Administration of high doses of angiotensin II (Ang II) results in natriuretic and
diuretic responses that are mediated by increases in renal perfusion pressure (RPP) …