[HTML][HTML] Solvent influence on the phase behavior and glass transition of Amorphous Solid Dispersions

S Dohrn, C Luebbert, K Lehmkemper… - European Journal of …, 2021 - Elsevier
Understanding the long-term stability of amorphous solid dispersions (ASDs) is important for
their successful approval for market. ASD stability does not only depend on the interplay …

Physical stability of amorphous solid dispersions: a physicochemical perspective with thermodynamic, kinetic and environmental aspects

X Lin, Y Hu, L Liu, L Su, N Li, J Yu, B Tang… - Pharmaceutical …, 2018 - Springer
Abstract Purpose Amorphous solid dispersions (ASDs) have been widely used in the
pharmaceutical industry for solubility enhancementof poorly water-soluble drugs. The …

[图书][B] Physical stability and crystallization inhibition

LS Taylor - 2015 - books.google.com
In order to successfully utilize amorphous solid dispersions (ASDs) to enhance drug
delivery, it is essential to maintain the amorphous form of the drug during the manufacturing …

Effects of additives on the physical stability and dissolution of polymeric amorphous solid dispersions: A review

J Li, Y Wang, D Yu - AAPS PharmSciTech, 2023 - Springer
Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …

The underestimated contribution of the solvent to the phase behavior of highly drug loaded amorphous solid dispersions

S Dedroog, E Boel, C Kindts, B Appeltans… - International Journal of …, 2021 - Elsevier
In spite of the fact that spray drying is widely applied for the formulation of amorphous solid
dispersions (ASDs), the influence of the solvent on the physical properties of the ASDs is still …

Amorphous solid dispersions: role of the polymer and its importance in physical stability and in vitro performance

Q Shi, H Chen, Y Wang, R Wang, J Xu, C Zhang - Pharmaceutics, 2022 - mdpi.com
Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …

The influence of hydrogen bonding between different crystallization tendency drugs and PVPVA on the stability of amorphous solid dispersions

J Wu, G Van den Mooter - International Journal of Pharmaceutics, 2023 - Elsevier
Amorphous solid dispersion (ASD) is one of the formulation strategies for drugs displaying
low solubility and low oral bioavailability. In this study, high drug-loaded ASDs of drugs with …

Factors influencing the crystallization-onset time of metastable ASDs

F Wolbert, IK Fahrig, T Gottschalk, C Luebbert… - Pharmaceutics, 2022 - mdpi.com
In formulation development, amorphous solid dispersions (ASD) are considered to improve
the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) …

Crystallization risk assessment of amorphous solid dispersions by physical shelf-life modeling: a practical approach

B Liu, F Theil, K Lehmkemper, D Gessner… - Molecular …, 2021 - ACS Publications
Amorphous solid dispersions (ASDs) of a poorly water-soluble active pharmaceutical
ingredient (API) in a polymer matrix can enhance the water solubility and therefore generally …

Characterization of amorphous solid dispersions: An update

X Ma, RO Williams III - Journal of Drug Delivery Science and Technology, 2019 - Elsevier
Amorphous solid dispersions (ASDs) are a promising formulation approach to improve the
solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. ASDs have …