Developmental potential of cloned embryos is related closely to epigenetic modification of
somatic cell genome. The present study was to investigate the effects of applying histone …

Accumulating evidence suggests that trichostatin A (TSA), a histone deacetylase inhibitor,
can increase the success rate of somatic cloning. The objective of this study was to …

Many different approaches have been developed to improve the efficiency of animal cloning
by somatic cell nuclear transfer (SCNT), one of which is to modify histone acetylation levels …

Somatic cell nuclear transfer (SCNT) efficiency is still low in rabbit. Previous studies
indicated that trichostatin A (TSA) treatment could improve cloning efficiency and term …

It has been reported that 5 or 50 nM trichostatin A (TSA) treatment after somatic cell nuclear
transfer (NT) improves the success rate of mouse cloning (Kishigami et al. 2006 Biochem …

Until now, the successful cloning of porcine by somatic cell nuclear transfer (SCNT) has
remained low. The effort of using Trichostatin A (TSA), a potent histone deacetylase inhibitor …

The present study was designed to examine the effect of trichostatin A (TSA), an inhibitor of
histone deacetylase, on development of porcine cloned embryos. Our results showed that …

Both preimplantation and full-term development of mouse somatic cell nuclear transfer
(SCNT) embryos are significantly enhanced by treatment with trichostatin A (TSA), an …

Recently, it has been reported that a new activation method, brief exposure to cycloheximide
before electrical activation, could increase development rates and reduce cell death. In our …

Epigenetic modification influences reprogramming and subsequent development of somatic
cell nuclear transfer (SCNT) embryos. Such modification includes an increase in histone …