Superantigen bound to major histocompatibility complex (MHC) products have been shown
to stimulate T cells in a V beta-specific manner. Mouse T cells bearing V beta 8.1 usually …

Recognition of conventional foreign antigen by T cells is determined by the expression of
multiple variable regions of both alpha and beta chains of the T cell receptor (TCR) …

We have recently shown that recognition of the mouse mammary tumor virus 9-associated
superantigen (vSAG-9) by murine V beta 17+ T cells is strongly influenced by the major …

Most, but not all, V beta 8.1+ T cells respond to M1s-1 and are clonally deleted in the thymus
of M1s-1-expressing animals. To formally examine the role of the TCR alpha-chain in …

Superantigen-MHC complexes are known to stimulate T cells primarily via the Vp element of
the T cell receptor. In this paper we identify a number of amino acid residues that define the …

The interaction of the T-cell receptor (TCR) with peptide antigen plus major
histocompatibility complex (MHC) protein requires both alpha and beta chains of the TCR …

CD4 T cell receptors (TCRs) recognize antigenic peptides presented by self major
histocompatibility complex (MHC) class II molecules as well as non-self MHC class II …

While recent evidence strongly suggests that the third complementarity determining regions
(CDR3s) of T cell receptors (TCRs) directly contact antigenic peptides bound to major …

The three-dimensional structure of an unglycosylated T cell antigen receptor (TCR) beta
chain has recently been determined to 1.7 A resolution. To investigate whether this soluble …

The current model of superantigen activity assumes that the superantigen simultaneously
binds to both the MHC molecule on the presenting cell and the V~ element of the TCR …