Targeted drug delivery to mammalian mitochondria in living cells

V Weissig - Expert Opinion on Drug Delivery, 2005 - Taylor & Francis
Mitochondrial dysfunction causes or contributes to a large number of human disorders
including neuromuscular and neurodegenerative diseases, diabetes, ischaemia …

Mitochondrial-targeted drug and DNA delivery

V Weissig - Critical Reviews™ in Therapeutic Drug Carrier …, 2003 - dl.begellhouse.com
The field of mitochondrial research is currently among the fastest growing disciplines in
biomedicine. Approximately 12,000 articles on mitochondria have been published since the …

Drug delivery to mitochondria: the key to mitochondrial medicine

MP Murphy, RAJ Smith - Advanced drug delivery reviews, 2000 - Elsevier
The major function of mitochondria in human cells is to provide ATP by oxidative
phosphorylation. However, mitochondria have many other roles including the modulation of …

Power of mitochondrial drug delivery systems to produce innovative nanomedicines

Y Yamada, M Hibino, D Sasaki, J Abe… - Advanced Drug Delivery …, 2020 - Elsevier
Mitochondria carry out various essential functions including ATP production, the regulation
of apoptosis and possess their own genome (mtDNA). Delivering target molecules to this …

Molecular vehicles for mitochondrial chemical biology and drug delivery

S Rin Jean, DV Tulumello, SP Wisnovsky… - ACS chemical …, 2014 - ACS Publications
The mitochondria within human cells play a major role in a variety of critical processes
involved in cell survival and death. An understanding of mitochondrial involvement in …

Mitochondrial medicine: pharmacological targeting of mitochondria in disease

JS Armstrong - British journal of pharmacology, 2007 - Wiley Online Library
Mitochondria play a central role in cell life and death and are known to be important in a
wide range of diseases including the cancer, diabetes, cardiovascular disease, and the age …

Delivery to mitochondria: a narrower approach for broader therapeutics

SS Malhi, RSR Murthy - Expert opinion on drug delivery, 2012 - Taylor & Francis
Introduction: Research has revealed a relationship between mitochondrial dysfunction and
diseases such as diabetes, ischemia–reperfusion injury, cancer and many more. As a result …

Targeting large molecules to mitochondria

A Muratovska, RN Lightowlers, RW Taylor… - Advanced drug delivery …, 2001 - Elsevier
Mitochondrial function is central to a range of cell processes and mitochondrial dysfunction
contributes to a number of human diseases. Consequently there is growing interest in …

Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases

Y Yamada, H Harashima - Advanced Drug Delivery Reviews, 2008 - Elsevier
Mitochondrial dysfunction has been implicated in a variety of human disorders—the so-
called mitochondrial diseases. Therefore, the organelle is a promising therapeutic drug …

Targeting drugs to mitochondria

A Heller, G Brockhoff, A Goepferich - European journal of pharmaceutics …, 2012 - Elsevier
Mitochondria are of an increasing interest in pharmaceutical and medical research since it
has been reported that dysfunction of these organelles contributes to several diseases with …