Molecular mechanisms of oxidative stress in asthma

C Michaeloudes, H Abubakar-Waziri, R Lakhdar… - Molecular aspects of …, 2022 - Elsevier
The lungs are exposed to reactive oxygen species oxygen (ROS) produced as a result of
inhalation of oxygen, as well as smoke and other air pollutants. Cell metabolism and the …

Production and degradation of oxygen metabolites during inflammatory states in the human lung

VL Kinnula - Current Drug Targets-Inflammation & Allergy, 2005 - ingentaconnect.com
Lung represents a tissue that encounters a high oxidant burden but is also endowed with
efficient protection against oxygen and reactive oxygen species (ROS). The oxidant stress …

Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: antioxidant therapeutic targets

I Rahman - Current Drug Targets-Inflammation & Allergy, 2002 - ingentaconnect.com
Inflammatory lung diseases such as asthma and Chronic Obstructive Pulmonary Disease
(COPD) are characterised by systemic and local chronic inflammation and oxidative stress …

[PDF][PDF] Oxidative stress in the lung tissue—sources of reactive oxygen species and antioxidant defence

J Tkaczyk, M Vizek - Prague Med Rep, 2007 - orl.lf1.cuni.cz
Reactive oxygen species are oxygen-based molecules readily reacting with various
compounds. It is already known that they play significant role in many physiological as well …

Redox regulation of lung inflammation: role of NADPH oxidase and NF-κB signalling

H Yao, SR Yang, A Kode… - Biochemical Society …, 2007 - portlandpress.com
Regulation of reduction/oxidation (redox) state is critical for cell viability, activation,
proliferation and organ function, and imbalance of oxidant/antioxidant balance is implicated …

Reactive oxygen species and oxidative stress

C Migdal, M Serres - Medecine Sciences: M/S, 2011 - europepmc.org
Oxidative stress is defined as an imbalance between the production of reactive oxygen
species (ROS) and the antioxidant capacity of the cell. For long, ROS have been considered …

Oxidative stress and free radicals in COPD–implications and relevance for treatment

W Domej, K Oettl, W Renner - International journal of chronic …, 2014 - Taylor & Francis
Oxidative stress occurs when free radicals and other reactive species overwhelm the
availability of antioxidants. Reactive oxygen species (ROS), reactive nitrogen species, and …

Oxidative stress

I Rahman, W MacNee - COPD; Cellular and molec‑9 ular …, 2005 - api.taylorfrancis.com
Reactive oxygen species (ROS) such as superoxide anion (O2–) and the hydroxyl radical
(OH) are highly unstable species with unpaired electrons, capable of initiating oxidation …

Oxidative stress and redox regulation of lung inflammation in COPD

I Rahman, IM Adcock - European respiratory journal, 2006 - Eur Respiratory Soc
Reactive oxygen species, either directly or via the formation of lipid peroxidation products,
may play a role in enhancing inflammation through the activation of stress kinases (c-Jun …

Pulmonary strategies of antioxidant defense 1

JE Heffner, JE Repine - Am Rev Respir Dis, 1989 - atsjournals.org
Induction of oxidant stress either by raising ambient oxygen concentrations, adding toxins
that augment intracellular oxidant formation, generating ischemia followed by tissue …