Cigarette smoking, the principal aetiology of chronic obstructive pulmonary disease (COPD)
in the developed countries, delivers and generates oxidative stress within the lungs. This …

Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

Oxidative stress (OS) has greatly interested the research community in understanding
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …

Significance: An acute lack of oxygen in the lung causes hypoxic pulmonary
vasoconstriction, which optimizes gas exchange. In contrast, chronic hypoxia triggers a …

Redox reactions are intrinsically linked to energy metabolism. Therefore, redox processes
are indispensable for organismal physiology and life itself. The term reactive oxygen species …

Reactive oxygen species (ROS) are a family of molecules that are continuously produced
from oxygen consumption in aerobic cells. Controlled generation of ROS in normal cells …

Glutathione (γ-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular
antioxidant thiol and is central to redox defense during oxidative stress. GSH metabolism is …

Asthma is a chronic inflammatory disease of the airways related to epithelial damage,
bronchial hyperresponsiveness to contractile agents, tissue remodeling, and luminal …

Oxidative stress is a major driving mechanism in the pathogenesis of COPD. There is
increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in …

Oxidative stress is an imbalance between oxidants (reactive oxygen and nitrogen species)
and antioxidants that may affect lipids, DNA, carbohydrates and proteins. The lung is …