Animal models are commonly used to determine the efficacy of various antimicrobial agents
for treatment of bacterial endocarditis. Previously we have utilized an in vitro infection model …

We developed a mouse model of Staphylococcus aureus infective endocarditis to evaluate
the efficacy of experimental antibacterial compounds for this disease. Experimental infective …

Bacterial endocarditis is a difficult-to-curc infection, owing to (i) poor penetration of
antibiotics into infected vegetations;(ii) altered metabolic state of bacteria within the …

The ability to maximize bactericidal activity while minimizing toxicity is a therapeutic goal in
the treatment of infective endocarditis. We evaluated the impact of administering short …

We adapted an in vitro pharmacodynamic model of infection to incorporate simulated
endocardial vegetations. The bactericidal activities of teicoplanin, vancomycin, gentamicin …

The experimental animal model of endocarditis provides a rigorous test of antibiotic efficacy.
It is a reliable, easily reproducible model of severe infection which requires high in vivo …

Enterococci are the third most frequent cause of infective endocarditis. A high-inoculum
stationary-phase in vitro pharmacodynamic model with simulated endocardial vegetations …

In a rabbit model of Escherichia coli endocarditis, we studied the penetration into infected
vegetations and the antibacterial effect of ceftriaxone. Ceftriaxone was given at different …

Intravascular or cardiac endothelial lesions may become colonized during bacteraemic
episodes and lead to the development of bacterial endocarditis (BE). It has therefore long …

Comparison of Antimicrobial Agents as Therapy for Experimental Endocarditis Caused by
Methicillin-Resistant Staphylococcus aureus - PMC Back to Top Skip to main content NIH NLM …