Vitamin B 12 (cobalamin (Cbl)), in the cofactor forms methyl-Cbl and adenosyl-Cbl, is
required for the function of the essential enzymes methionine synthase and methylmalonyl …

Vitamin B 12 (cobalamin) is an essential micronutrient for human health, and mutation and
dysregulation of cobalamin metabolism are associated with serious diseases, such as …

Inherited disorders of vitamin B12 (cobalamin) have provided important clues to how this
vitamin, which is essential for hematological and neurological function, is transported and …

Inborn errors of vitamin B12 (cobalamin) metabolism are characterized by decreased
production of active cobalamin cofactors and subsequent deficiencies in the activities of …

Background Vitamin B12 (cobalamin) is an essential cofactor in several metabolic pathways.
Intracellular conversion of cobalamin to its two coenzymes, adenosylcobalamin in …

Vitamin B12 (cobalamin) is essential in animals for metabolism of branched chain amino
acids and odd chain fatty acids, and for remethylation of homocysteine to methionine. In the …

Abstract Vitamin B 12 (cobalamin, Cbl, B 12) is a water-soluble micronutrient synthesized
exclusively by a group of microorganisms. Human beings are unable to make B 12 and thus …

ABCD4, which belongs to the ABC protein subfamily D, plays a role in the transport of
cobalamin from lysosomes to the cytosol by cooperating with ATP‐binding and ATP …

Patients with the cblC vitamin B12 (cobalamin, cbl) disorder are defective in the intracellular
synthesis of adenosylcobalamin and methylcobalamin and have combined homocystinuria …

Mutations in cobalamin or B12 trafficking genes needed for cofactor assimilation and
targeting lead to inborn errors of cobalamin metabolism. The gene corresponding to one of …