The nephrotoxicity of amikacin (AK) was prevented with pentoxifylline (PTX) in a rat model.
Rats were received a single injection of AK (1.2 g/kg, ip) with or without PTX pretreatment …

Background Amikacin has the largest spectrum among aminoglycosides, its nephrotoxic
effect limits its utilization. Our purpose in this study is to review the protective effect of …

Aminoglycoside antibiotics have long been used in antibacterial therapy. Despite their
beneficial effects, aminoglycosides have considerable nephrotoxic and ototoxic side effects …

Gentamicin (GM) is a widely used antibiotic against serious and life-threatening infections,
but its usefulness is limited by the development of nephrotoxicity. Thus, the present study …

Amikacin (AK) has nephrotoxic side effects. AK‐induced nephrotoxicity may be the
consequence of oxidative stress and so anti‐oxidant agents could be useful in reducing AK …

We investigated whether thymoquinone (TQ) exerts a beneficial effect on renal injury due to
amikacin (AK) administration in rats. To generate kidney damage with AK, a single 1.2 g/kg …

We aimed to investigate the underlying mechanisms responsible for the renoprotective
effects of pentoxifylline (PTX) in gentamicin (GEN)-induced nephropathy. On this purpose …

Amikacin is a commonly used antibacterial drug that can cause significant nephrotoxic
effects in both humans and experimental animals. It has been reported that one mechanism …

Background Aminoglycoside antibiotics are widely used potent bactericidal drugs. However,
nephrotoxicity side effects via oxidant injury limit their effectiveness. Erythropoietin (Epo) has …

Tumor necrosis factor-α (TNF-α) is a mediator of inflammation in human and animal renal
disease. Pentoxiphylline (PTX) is an inhibitor of TNF-α. In this study we examined the effects …