Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1)

JS Kooij, AM Boonstra, SH Vermeulen… - American Journal of …, 2008 - Wiley Online Library
In this pharmacogenetic study in adults with ADHD (n= 42), a stratified analysis was
performed of the association between response to methylphenidate (MPH), assessed under …

Association of dopamine, serotonin, and nicotinic gene polymorphisms with methylphenidate response in ADHD

H Tharoor, EA Lobos, RD Todd… - American Journal of …, 2008 - Wiley Online Library
Gene polymorphisms of the 3′ untranslated region (3′‐UTR) of the dopamine transporter
(DAT1), Dopamine receptor exon 3 D4 variable number tandem repeat (DRD4VNTR) …

Meta-analysis of the association between dopamine transporter genotype and response to methylphenidate treatment in ADHD

J Kambeitz, M Romanos, U Ettinger - The pharmacogenomics journal, 2014 - nature.com
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent childhood-onset
neuropsychiatric disorder. Treatment with methylphenidate, which blocks dopamine and …

Polymorphisms of the dopamine transporter gene: influence on response to methylphenidate in attention deficit-hyperactivity disorder

T Roman, LA Rohde, MH Hutz - American Journal of Pharmacogenomics, 2004 - Springer
Attention deficit-hyperactivity disorder (ADHD) is a very common and heterogeneous
childhood-onset psychiatric disorder, affecting between 3% and 5% of school age children …

Pharmacogenetics of methylphenidate response in attention deficit/hyperactivity disorder: Association with the dopamine transporter gene (SLC6A3)

D Purper‐Ouakil, M Wohl, S Orejarena… - American Journal of …, 2008 - Wiley Online Library
Pharmacogenetic studies investigating the 40‐bp VNTR polymorphism at SLC6A3 and
methylphenidate response have shown conflicting results and large differences in study …

No significant association between genetic variants in 7 candidate genes and response to methylphenidate treatment in adult patients with ADHD

V Contini, MM Victor, GP Bertuzzi… - Journal of clinical …, 2012 - journals.lww.com
Results from pharmacogenetic investigations of methylphenidate (MPH) response in
patients with ADHD are still inconsistent, especially among adults. This study investigates …

Absence of association with DAT1 polymorphism and response to methylphenidate in a sample of adults with ADHD

E Mick, J Biederman, T Spencer… - American Journal of …, 2006 - Wiley Online Library
A polymorphism in the dopamine transporter gene (DAT1) has been previously associated
with ADHD and methylphenidate has been hypothesized to block the dopamine transporter …

[HTML][HTML] Dopamine transporter 3′-UTR VNTR genotype and ADHD: a pharmaco-behavioural genetic study with methylphenidate

R Joober, N Grizenko, S Sengupta, LB Amor… - …, 2007 - nature.com
We sought to test the hypothesis that the variable number of tandem repeat (VNTR)
polymorphism in the 3′-untranslated region (3′-UTR) of the SLC6A3 gene modulates …

Dopamine transporter genotype and stimulant side effect factors in youth diagnosed with attention-deficit/hyperactivity disorder

R Gruber, R Joober, N Grizenko… - Journal of Child and …, 2009 - liebertpub.com
The dopamine transporter locus (DAT1) has been studied as a risk factor for attention-
deficit/hyperactivity disorder (ADHD) and in pharmacogenetic studies of stimulant response …

[HTML][HTML] Dopamine transporter genotype and methylphenidate dose response in children with ADHD

MA Stein, ID Waldman, CS Sarampote… - …, 2005 - nature.com
Stimulant medications, such as methylphenidate (MPH), are the most commonly used,
effective treatment for ADHD. MPH acts primarily by inhibiting the dopamine transporter …